HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PKHG6 (Q3KR16)
Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
Gene: PLEKHG6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 790
+	Hs
		925497 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG2_HUMAN (8-772): 2.09e-98: 329: 16.22
+	Hs
		925271 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG7_HUMAN (39-724): 1.18e-93: 312: 14.74
+	Hs
		564524 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG7_HUMAN (39-724): 1.18e-93: 312: 14.74
+	Hs
		925527 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPT13_HUMAN (1-587): 3.2e-94: 310: 12.73
+	Hs
		925718 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV3_HUMAN (72-664): 7.96e-91: 305: 14.43
+	Hs
		855782 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV2_HUMAN (81-644): 5.43e-90: 304: 17.50
+	Hs
		545368 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ARHG7_HUMAN (39-724): 1.18e-93: 312: 14.74
+	Hs
		548678 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV_HUMAN (99-662): 1.12e-87: 297: 14.98
+	Hs
		925727 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG1_HUMAN (109-746): 6.19e-85: 297: 16.98
+	Hs
		564737 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHG1_HUMAN (109-746): 6.19e-85: 297: 16.98
+	Hs
		167081 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGB_HUMAN (22-750): 2.8e-83: 292: 17.48
+	Hs
		925289 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG6_HUMAN (42-766): 8.59e-85: 287: 13.17
+	Hs
		564535 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG6_HUMAN (42-766): 8.59e-85: 287: 13.17
+	Gg
		1141019 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		ARHG6_CHICK (45-757): 7.32e-82: 279: 13.92
+	Hs
		925624 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ECT2_HUMAN (77-645): 3.51e-80: 277: 19.26
+	Hs
		925649 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG4_HUMAN (120-572): 1.48e-78: 268: 16.21
+	Hs
		925512 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGQ_HUMAN (127-518): 1.06e-71: 253: 20.14
+	Hs
		279854 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TRIO_HUMAN (150-719): 1.63e-60: 225: 14.66
+	Hs
		224711 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KALRN_HUMAN (112-761): 6.57e-56: 211: 13.75
+	Hs
		500934 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MCF2_HUMAN (162-356): 3.28e-09: 62.8: 28.28