HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: MRCKG (Q6DT37)
Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42-binding protein kinase gamma) (DMPK-like gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (MRCK gamma) (MRCKG) (Myotonic dystrophy protein kinase-like gamma) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15194684
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1551
+	Hs
		564571 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MRCKG_HUMAN (1-1551): 0: 1461: 100.00
+	Hs
		925766 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MRCKB_HUMAN (2-1529): 0: 1261: 41.72
+	Hs
		564758 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MRCKB_HUMAN (2-1529): 0: 1261: 41.72
+	Hs
		925344 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MRCKA_HUMAN (2-1539): 0: 1257: 43.49
+	Hs
		564564 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MRCKA_HUMAN (2-1539): 0: 1257: 43.49
+	Mm
		925783 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		TNIK_MOUSE (47-1344): 0: 693: 15.57
+	Hs
		925434 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MINK1_HUMAN (47-1344): 0: 620: 15.64
+	Hs
		564611 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MINK1_HUMAN (47-1344): 0: 620: 15.64
+	Hs
		647868 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MARK3_HUMAN (17-767): 2.1e-154: 490: 16.23
+	Hs
		564418 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MARK3_HUMAN (17-767): 2.1e-154: 490: 16.23
+	Hs
		925606 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TAOK3_HUMAN (48-878): 5.36e-140: 456: 15.02
+	Hs
		148653 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CTRO_HUMAN (11-871): 6.09e-129: 446: 26.03
+	Hs
		925229 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DMPK_HUMAN (2-544): 4.38e-132: 425: 47.09
+	Hs
		568619 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KAPCA_HUMAN (43-371): 1.08e-128: 406: 33.14
+	Mm
		823530 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CTRO_MOUSE (11-890): 3.45e-115: 405: 25.00
+	Hs
		254468 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ROCK2_HUMAN (440-918): 1.53e-15: 85: 15.51
+	Hs
		254445 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ROCK2_HUMAN (440-918): 1.53e-15: 85: 15.51
+	Hs
		925253 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ROCK1_HUMAN (449-918): 2.21e-14: 81.1: 12.62
+	Hs
		564514 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ROCK1_HUMAN (449-918): 2.21e-14: 81.1: 12.62
+	Dm
		776923 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q9VXE3_DROME (329-938): 4.96e-13: 76.5: 12.23