HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: TRAF7 (Q6Q0C0)
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
Gene: TRAF7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 33961781, 34215617
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0031410 - cytoplasmic vesicle
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 670
+	Hs
		564578 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		545451 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		894143 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		900602 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		TRAF7_HUMAN (1-670): 1.55e-180: 530: 100.00
+	Hs
		951210 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		FBXW7_HUMAN (70-499): 3.77e-45: 173: 12.60
+	Mm
		892718 CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31		LIS1_MOUSE (140-426): 1.46e-23: 105: 10.82
+	Hs
		436191 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		LIS1_HUMAN (140-426): 1.68e-23: 105: 10.82
+	Hs
		900348 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		WDR5_HUMAN (99-424): 5.66e-20: 93.7: 10.21
+	Hs
		436239 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		WDR5_HUMAN (99-424): 5.66e-20: 93.7: 10.21