HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0001764 - neuron migration GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 788
+	Hs
		564584 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		545461 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		1183120 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		892447 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		951102 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		894157 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		647868 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		564418 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		545213 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647958 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647855 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647872 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647856 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		894319 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		MARK4_HUMAN (3-788): 0: 572: 48.20
+	Hs
		925283 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		545381 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Hs
		894016 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		MELK_HUMAN (44-788): 7.75e-161: 483: 25.03
+	Rn
		871319 RAC1_RAT (1-192): 3.81e-86: 253: 100.00		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00
+	Hs
		1219185 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		BRSK2_HUMAN (43-481): 4.15e-137: 424: 37.11
+	Hs
		892473 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		BRSK2_HUMAN (43-481): 4.15e-137: 424: 37.11