Protein: ASSY
Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)

Gene: ASSY, ASS1
Organism: Homo sapiens
Interactions: 117
UniProt ID: P00966

Gene Ontology (top 5):
GO:0000050 - urea cycle
GO:0000052 - citrulline metabolic process
GO:0000053 - argininosuccinate metabolic process
GO:0001822 - kidney development
GO:0001889 - liver development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

343928

ASSY
Argininosuccinate synthase

3

3

High-throughput

0.862

High

343929

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.656

High

343940

PYC
Pyruvate carboxylase, mitochondrial

2

0

High-throughput

0.602

High

343987

Z354C
Zinc finger protein 354C

2

0

High-throughput

0.602

High

344021

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

2

0

High-throughput

0.602

High

226206

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

344022

ANM7
Protein arginine N-methyltransferase 7

1

0

Small-scale

0.561

High

343961

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.541

High

343976

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.541

High

334096

LDHA
L-lactate dehydrogenase A chain

1

1

High-throughput

0.536

High

343946

USF1
Upstream stimulatory factor 1

1

3

High-throughput

0.536

High

343955

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

343970

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.536

High

343997

NGN1
Neurogenin-1

1

1

High-throughput

0.536

High

238324

JAK2
Tyrosine-protein kinase JAK2

1

0

High-throughput

0.518

High

343944

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.518

High

344011

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

62074

EPAB2
Embryonic polyadenylate-binding protein 2

1

0

High-throughput

0.513

High

208496

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.513

High

262666

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.513

High

343931

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.513

High

343933

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.513

High

343936

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

343938

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.513

High

343939

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

343949

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

0

High-throughput

0.513

High

343953

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.513

High

343963

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

343964

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

343969

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

343989

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.513

High

344003

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.513

High

344004

SORT
Sortilin

1

0

High-throughput

0.513

High

344005

GDF15
Growth/differentiation factor 15

1

0

High-throughput

0.513

High

344010

BTBD1
BTB/POZ domain-containing protein 1

1

0

High-throughput

0.513

High

344015

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

High-throughput

0.513

High

344020

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

344025

OAZ3
Ornithine decarboxylase antizyme 3

1

0

High-throughput

0.513

High

344016

NMRL1
NmrA-like family domain-containing protein 1

1

0

Small-scale

0.493

High

343941

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.489

High

344029

NGN3
Neurogenin-3

1

1

High-throughput

0.489

High

343935

ARAF
Serine/threonine-protein kinase A-Raf

1

0

Small-scale

0.486

High

343954

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.486

High

343934

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

343965

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

243769

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

319100

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.479

High

343932

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

343960

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.479

High

343966

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

343968

1433F
14-3-3 protein eta

1

1

High-throughput

0.479

High

343972

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

343975

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

343984

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

343985

ASB18
Ankyrin repeat and SOCS box protein 18

1

1

High-throughput

0.479

High

344000

ASB9
Ankyrin repeat and SOCS box protein 9

1

1

High-throughput

0.479

High

344024

HDAC6
Histone deacetylase 6

1

2

High-throughput

0.479

High

344031

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.479

High

343930

MT2
Metallothionein-2

1

0

High-throughput

0.460

High

343971

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

Small-scale

0.460

High

325579

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

343937

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

343943

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

343947

SP100
Nuclear autoantigen Sp-100

1

0

High-throughput

0.458

High

343948

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

343952

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

343956

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

343957

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

343959

SMCA2
Probable global transcription activator SNF2L2

1

0

High-throughput

0.458

High

343962

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

343973

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

343979

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.458

High

343980

FTM
Protein fantom

1

0

High-throughput

0.458

High

343981

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

343986

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

343990

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

343995

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

343998

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

343999

OPTN
Optineurin

1

0

High-throughput

0.458

High

344002

SCLT1
Sodium channel and clathrin linker 1

1

0

High-throughput

0.458

High

344006

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

344009

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

344017

ANLN
Anillin

1

0

High-throughput

0.458

High

344018

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

344026

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.458

High

344028

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

Small-scale

0.458

High

343967

CDR2
Cerebellar degeneration-related protein 2

1

0

Small-scale

0.438

High

343977

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.437

High

344008

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

344019

CAH10
Carbonic anhydrase-related protein 10

3

0

High-throughput

0.347

High

343983

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

344013

AKTIP
AKT-interacting protein

1

0

High-throughput

0.282

High

306378

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low

307305

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

343942

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.279

Low

343945

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

343950

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

343951

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.279

Low

343958

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.279

Low

343974

ICAM4
Intercellular adhesion molecule 4

1

0

High-throughput

0.279

Low

343982

F117B
Protein FAM117B

1

0

High-throughput

0.279

Low

343991

LGI2
Leucine-rich repeat LGI family member 2

1

0

High-throughput

0.279

Low

343992

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

1

0

High-throughput

0.279

Low

344001

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.279

Low

344012

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.279

Low

344014

SFXN1
Sideroflexin-1

1

0

High-throughput

0.279

Low

344023

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

344030

MPC1
Mitochondrial pyruvate carrier 1

1

0

High-throughput

0.279

Low

344007

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

225450

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

343978

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

343988

DOPP1
Dolichyldiphosphatase 1

1

0

High-throughput

0.249

Low

343993

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

343994

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

343996

PHIP
PH-interacting protein

1

0

High-throughput

0.249

Low

344027

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024