HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ARAP2 (Q8WZ64)
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (Centaurin-delta-1) (Cnt-d1) (Protein PARX)
Gene: ARAP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	32203420, 31871319
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~Ras, RA~Ras, Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1704
+	Hs
		925529 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARAP1_HUMAN (476-1586): 0: 791: 40.30
+	Hs
		925736 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP1_HUMAN (361-914): 2.07e-110: 374: 17.98
+	Hs
		925690 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG23_HUMAN (863-1668): 3.87e-104: 369: 14.32
+	Hs
		925420 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG12_HUMAN (746-1298): 7.69e-97: 335: 17.14
+	Ce
		88245 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		D3YT54_CAEEL (1073-1670): 7.72e-101: 339: 14.29
+	Hs
		925724 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ASAP1_HUMAN (309-938): 1.04e-91: 326: 16.96
+	Hs
		302639 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FA13A_HUMAN (1101-1669): 2.05e-86: 308: 14.14
+	Hs
		925567 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG09_HUMAN (767-1298): 3.16e-88: 307: 15.72
+	Hs
		925551 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP2_HUMAN (414-942): 1.07e-84: 306: 17.04
+	Hs
		925378 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG27_HUMAN (873-1298): 5.3e-86: 304: 17.61
+	Hs
		64688 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG32_HUMAN (1029-1446): 2.99e-77: 287: 18.20
+	Mm
		925803 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG32_MOUSE (1029-1446): 2.82e-77: 287: 18.43
+	Hs
		64652 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RHG32_HUMAN (1029-1446): 2.99e-77: 287: 18.20
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (907-1302): 1.05e-83: 285: 17.89
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (1107-1297): 3.11e-67: 237: 24.50
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (1107-1297): 1.94e-66: 230: 23.50
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (1107-1297): 4.66e-64: 228: 23.50
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (388-648): 1.49e-17: 91.6: 12.23
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (445-573): 2.88e-17: 90.1: 13.70
+	Hs
		564562 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RHG21_HUMAN (388-648): 1.49e-17: 91.6: 12.23