HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: RGAP1 (Q9H0H5)
Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
Gene: RACGAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 632
+	Hs
		200213 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP3_HUMAN (1-627): 7.14e-96: 319: 13.81
+	Hs
		925395 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP1_HUMAN (14-627): 6.52e-93: 311: 12.74
+	Hs
		63073 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG42_HUMAN (12-585): 7.62e-86: 288: 17.71
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (204-539): 4.25e-88: 283: 24.09
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (270-539): 7.95e-90: 283: 28.10
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (239-539): 1.23e-86: 279: 28.20
+	Hs
		147862 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG33_HUMAN (214-631): 1.12e-75: 265: 19.49
+	Hs
		253337 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP2_HUMAN (14-626): 2.29e-73: 257: 11.95
+	Hs
		925314 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG44_HUMAN (65-625): 8.78e-75: 257: 14.36
+	Hs
		245184 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		OPHN1_HUMAN (12-627): 1.92e-71: 248: 15.12
+	Hs
		925242 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG05_HUMAN (337-565): 1.07e-65: 236: 27.83
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (338-629): 3.37e-63: 229: 26.49
+	Hs
		925394 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG22_HUMAN (346-628): 1.28e-65: 229: 28.91
+	Hs
		925420 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG12_HUMAN (329-541): 2.52e-64: 229: 27.44
+	Hs
		925378 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG27_HUMAN (328-540): 1.9e-63: 227: 30.23
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (331-627): 5.12e-62: 220: 27.24
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (325-540): 3.57e-61: 212: 27.85
+	Mm
		925793 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		ABR_MOUSE (362-505): 1.51e-22: 104: 43.15
+	Hs
		506566 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		BCR_HUMAN (362-505): 1.77e-19: 95.5: 39.73
+	Mm
		925798 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		BCR_MOUSE (362-505): 1.77e-19: 95.5: 39.73