HitPredict

Interactor 1: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Interactor 2: ASB4 (Q9Y574)
Ankyrin repeat and SOCS box protein 4 (ASB-4)
Gene: ASB4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	17636018, 24337577
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~SOCS_box
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005829 - cytosol GO:0031466 - Cul5-RING ubiquitin ligase complex GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 780 Hs			1 426
+	Hs
		1043331 CUL4A_HUMAN (16-780): 0: 744: 24.48		ASB4_HUMAN (1-426): 3.59e-96: 296: 100.00
+	Hs
		1021397 CUL3_HUMAN (8-780): 0: 754: 22.96		ANK3_HUMAN (80-407): 1.1e-72: 250: 19.37
+	Hs
		1021398 CUL4A_HUMAN (16-780): 0: 744: 24.48		ANK3_HUMAN (80-407): 1.1e-72: 250: 19.37
+	Hs
		1274023 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB2_HUMAN (20-346): 2.44e-56: 197: 20.67
+	Hs
		166925 CUL3_HUMAN (8-780): 0: 754: 22.96		ANR28_HUMAN (79-399): 4.92e-66: 229: 18.04
+	Hs
		1274043 CUL5_HUMAN (1-780): 0: 792: 100.00		TNKS2_HUMAN (7-228): 1.37e-49: 182: 18.50
+	Hs
		1041153 CUL1_HUMAN (11-780): 0: 748: 27.84		ASB2_HUMAN (20-346): 2.44e-56: 197: 20.67
+	Hs
		1043172 CUL4A_HUMAN (16-780): 0: 744: 24.48		ASB2_HUMAN (20-346): 2.44e-56: 197: 20.67
+	Hs
		1262947 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB5_HUMAN (141-420): 2.81e-38: 142: 21.00
+	Hs
		862036 CUL3_HUMAN (8-780): 0: 754: 22.96		DAPK1_HUMAN (133-409): 1.92e-47: 176: 14.19
+	Hs
		1274021 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB16_HUMAN (4-217): 3.11e-26: 111: 20.54
+	Hs
		1263852 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB10_HUMAN (12-164): 6.57e-24: 105: 17.05
+	Hs
		1041441 CUL2_HUMAN (6-780): 0: 699: 26.36		ASB2_HUMAN (20-346): 2.44e-56: 197: 20.67
+	Hs
		1042054 CUL3_HUMAN (8-780): 0: 754: 22.96		ANR52_HUMAN (110-341): 5.04e-36: 142: 21.98
+	Hs
		1173122 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB18_HUMAN (3-249): 5.75e-21: 96.6: 18.01
+	Hs
		1041199 CUL1_HUMAN (11-780): 0: 748: 27.84		Q9H4D1_HUMAN (8-175): 3.96e-31: 128: 18.54
+	Hs
		883509 CUL1_HUMAN (11-780): 0: 748: 27.84		RIPK4_HUMAN (8-175): 2.18e-31: 128: 18.54
+	Hs
		556700 CUL3_HUMAN (8-780): 0: 754: 22.96		ANK1_HUMAN (221-417): 2.48e-22: 101: 12.18
+	Hs
		1274049 CUL5_HUMAN (1-780): 0: 792: 100.00		ASB8_HUMAN (79-213): 2.57e-09: 60.1: 31.62
+	Hs
		1043588 CUL4B_HUMAN (16-780): 0: 736: 25.39		ASB8_HUMAN (79-213): 2.57e-09: 60.1: 31.62