HitPredict - High confidence protein-protein interactions

Interactor 1: IST1 (P53990)
IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28)
Gene: IST1

Interactor 2: IST1 (P53990)
IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28)
Gene: IST1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.666

Property	Details
Experiments	19525971
Identification Methods	transmission electron microscopy, light scattering
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ist1~Ist1
Common GO terms	GO:0000785 - chromatin GO:0005576 - extracellular region GO:0005635 - nuclear envelope GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment GO:0005813 - centrosome and 21 others more... GO:0005829 - cytosol GO:0008104 - intracellular protein localization GO:0015031 - protein transport GO:0019904 - protein domain specific binding GO:0030496 - midbody GO:0035578 - azurophil granule lumen GO:0036258 - multivesicular body assembly GO:0043231 - intracellular membrane-bounded organelle GO:0044877 - protein-containing complex binding GO:0045184 - establishment of protein localization GO:0045296 - cadherin binding GO:0045862 - positive regulation of proteolysis GO:0048668 - collateral sprouting GO:0048672 - positive regulation of collateral sprouting GO:0051301 - cell division GO:0061640 - cytoskeleton-dependent cytokinesis GO:0061952 - midbody abscission GO:0070062 - extracellular exosome GO:0090541 - MIT domain binding GO:0090543 - Flemming body GO:1904903 - ESCRT III complex disassembly
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	364
Hs

1	364

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Last updated: 11Aug2025