Protein: IST1
Vacuolar protein sorting-associated protein IST1 (Increased sodium tolerance protein 1)

Gene: IST1
Organism: Saccharomyces cerevisiae S288C
Interactions: 41
UniProt ID: P53843

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005768 - endosome
GO:0008104 - intracellular protein localization
GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway
GO:0042030 - ATPase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

923806

DID2
Vacuolar protein-sorting-associated protein 46

9

13

Small-scale

0.970

High

815040

SNF7
Vacuolar-sorting protein SNF7

3

14

Small-scale

0.827

High

781014

VPS24
Vacuolar protein-sorting-associated protein 24

3

13

Small-scale

0.821

High

781331

DID4
DOA4-independent degradation protein 4

3

13

Small-scale

0.821

High

923807

VPS60
Vacuolar protein-sorting-associated protein 60

2

11

Small-scale

0.754

High

923808

VPS20
Vacuolar protein sorting-associated protein 20

2

11

Small-scale

0.754

High

923805

IST1
Vacuolar protein sorting-associated protein IST1

1

2

High-throughput

0.698

High

915377

VPS4
Vacuolar protein sorting-associated protein 4

4

8

Small-scale

0.686

High

864573

YJE9
Uncharacterized protein YJL049W

1

0

Small-scale

0.589

High

738597

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

1

High-throughput

0.588

High

733617

PROB
Glutamate 5-kinase

2

0

High-throughput

0.563

High

843117

XKS1
Xylulose kinase

2

0

High-throughput

0.563

High

478420

EI2BG
Translation initiation factor eIF2B subunit gamma

2

1

High-throughput

0.537

High

555319

EI2BD
Translation initiation factor eIF2B subunit delta

2

2

High-throughput

0.537

High

575359

EI2BA
Translation initiation factor eIF2B subunit alpha

2

2

High-throughput

0.537

High

738682

EI2BB
Translation initiation factor eIF2B subunit beta

2

2

High-throughput

0.537

High

923811

VTA1
Vacuolar protein sorting-associated protein VTA1

1

0

High-throughput

0.518

High

509668

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

793406

ATM
Serine/threonine-protein kinase TEL1

1

1

High-throughput

0.489

High

793442

ATR
Serine/threonine-protein kinase MEC1

1

1

High-throughput

0.489

High

488982

SWI6
Regulatory protein SWI6

1

0

High-throughput

0.458

High

592412

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

885042

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

802960

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.438

High

918635

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.438

High

453723

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

524745

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

835851

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.426

High

893138

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

0

High-throughput

0.426

High

531830

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.407

High

478632

IF2B
Eukaryotic translation initiation factor 2 subunit beta

2

0

High-throughput

0.307

High

918879

RRP46
Exosome complex component RRP46

2

0

High-throughput

0.307

High

923809

COG8
Conserved oligomeric Golgi complex subunit 8

2

0

High-throughput

0.307

High

923812

RRP40
Exosome complex component RRP40

2

0

High-throughput

0.307

High

835514

BUB1
Spindle assembly checkpoint serine/threonine-protein kinase BUB1

1

0

High-throughput

0.279

Low

792665

AP2A
AP-2 complex subunit alpha

1

0

High-throughput

0.269

Low

707811

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

923810

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

743709

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.238

Low

923813

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025