HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PAK6 (Q9NQU5)
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
Gene: PAK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.893

Property	Details
Experiments	11773441, 25301945, 26375402, 32707033
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 681
+	Hs
		925692 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK5_HUMAN (1-676): 1.65e-174: 516: 44.51
+	Hs
		330967 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330841 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		564425 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		AKT2_HUMAN (285-680): 9.96e-139: 416: 20.99
+	Hs
		681775 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AKT1_HUMAN (349-680): 1.47e-131: 398: 23.10
+	Hs
		568619 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Ce
		975572 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		PK1_CAEEL (161-680): 9.16e-127: 389: 33.58
+	Dd
		332055 RACF1_DICDI (1-179): 2.03e-96: 279: 72.63		PAKB_DICDI (388-676): 6.93e-65: 231: 45.39
+	Dd
		710119 RACA_DICDI (1-187): 1.11e-84: 263: 65.24		PAKB_DICDI (388-676): 6.93e-65: 231: 45.39
+	Hs
		925763 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		M4K5_HUMAN (391-667): 6.69e-55: 203: 41.05
+	Mm
		103566 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		G5E884_MOUSE (3-205): 2.63e-39: 154: 17.16
+	Mm
		292040 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		PAK1_MOUSE (3-205): 7.18e-39: 153: 16.67
+	Hs
		925244 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Mm
		103575 RHOQ_MOUSE (4-187): 8.33e-85: 250: 64.13		G5E884_MOUSE (3-205): 2.63e-39: 154: 17.16
+	Hs
		564505 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK1_HUMAN (3-205): 4.77e-39: 153: 17.16
+	Mm
		103567 RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67		G5E884_MOUSE (3-205): 2.63e-39: 154: 17.16
+	Hs
		277602 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK3_HUMAN (3-215): 8.38e-34: 138: 14.78
+	Hs
		925245 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK2_HUMAN (9-162): 1.11e-33: 137: 18.63
+	Mm
		925809 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		PAK2_MOUSE (9-162): 9.08e-34: 137: 19.26
+	Hs
		564507 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK2_HUMAN (9-162): 1.11e-33: 137: 18.63