Protein: IST1
IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28)

Gene: IST1
Organism: Homo sapiens
Interactions: 101
UniProt ID: P53990

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005576 - extracellular region
GO:0005635 - nuclear envelope
GO:0005793 - endoplasmic reticulum-Golgi intermediate compartment
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925683

CHM1A
Charged multivesicular body protein 1a

5

17

High-throughput

0.921

High

925655

CHM1B
Charged multivesicular body protein 1b

5

18

Small-scale

0.916

High

925689

SPAST
Spastin

4

8

Small-scale

0.696

High

568323

ACPH
Acylamino-acid-releasing enzyme

5

0

High-throughput

0.692

High

925681

CHM4B
Charged multivesicular body protein 4b

1

11

High-throughput

0.691

High

925688

CHMP5
Charged multivesicular body protein 5

1

18

High-throughput

0.691

High

925694

UBQL1
Ubiquilin-1

3

1

High-throughput

0.675

High

925644

ATX1
Ataxin-1

4

0

High-throughput

0.674

High

925643

IST1
IST1 homolog

1

2

Small-scale

0.666

High

925695

VPS4A
Vacuolar protein sorting-associated protein 4A

2

8

High-throughput

0.628

High

925702

CAN7
Calpain-7

2

1

Small-scale

0.625

High

925691

UBQL2
Ubiquilin-2

2

1

High-throughput

0.606

High

925676

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

0

High-throughput

0.602

High

925697

VP9D1
VPS9 domain-containing protein 1

2

0

High-throughput

0.595

High

650662

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

2

0

High-throughput

0.585

High

925690

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

2

0

High-throughput

0.585

High

336645

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

395747

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

619635

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

169485

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.536

High

276448

PDCD6
Programmed cell death protein 6

1

3

High-throughput

0.536

High

296469

STAM2
Signal transducing adapter molecule 2

1

2

High-throughput

0.536

High

483053

CLCA
Clathrin light chain A

1

1

High-throughput

0.536

High

483314

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

901145

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.536

High

925671

STAM1
Signal transducing adapter molecule 1

1

2

High-throughput

0.536

High

925684

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

1

High-throughput

0.536

High

249112

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.518

High

292597

RENR
Renin receptor

1

0

High-throughput

0.513

High

618376

TSN8
Tetraspanin-8

1

0

High-throughput

0.513

High

925647

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

925670

TFG
Protein TFG

1

0

High-throughput

0.513

High

925674

MB12A
Multivesicular body subunit 12A

1

0

High-throughput

0.513

High

925698

NTNG1
Netrin-G1

1

0

High-throughput

0.513

High

925699

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

828188

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.493

High

925700

MB212
Protein mab-21-like 2

1

1

High-throughput

0.489

High

131850

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

Small-scale

0.480

High

185550

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

241185

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

389178

FINC
Fibronectin

1

1

High-throughput

0.479

High

425397

ISG15
Ubiquitin-like protein ISG15

1

1

Small-scale

0.479

High

583070

VATB1
V-type proton ATPase subunit B, kidney isoform

1

1

High-throughput

0.479

High

925648

CDC20
Cell division cycle protein 20 homolog

1

1

Small-scale

0.479

High

925651

NAA25
N-alpha-acetyltransferase 25, NatB auxiliary subunit

1

1

High-throughput

0.479

High

925664

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

925667

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

925669

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

925675

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

925693

FZR1
Fizzy-related protein homolog

1

1

Small-scale

0.479

High

925656

Q7Z479
Calpain-7

1

1

High-throughput

0.470

High

190008

TOX3
TOX high mobility group box family member 3

1

0

High-throughput

0.460

High

547573

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

555974

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

565251

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

629681

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

767142

MERL
Merlin

1

0

High-throughput

0.458

High

791213

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

830404

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

900743

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.458

High

925645

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

925646

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

925653

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.458

High

925657

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

925658

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

925661

RHG18
Rho GTPase-activating protein 18

1

0

High-throughput

0.458

High

925679

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

925692

ANC2
Anaphase-promoting complex subunit 2

1

0

Small-scale

0.458

High

800468

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.445

High

925696

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.445

High

925686

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

330090

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

369169

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

689813

CD27
CD27 antigen

1

0

High-throughput

0.426

High

925659

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

925685

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

925687

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

484448

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

925652

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.279

Low

925660

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

925666

S2540
Mitochondrial glutathione transporter SLC25A40

1

0

High-throughput

0.279

Low

925668

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

1

0

High-throughput

0.279

Low

925673

ISOC1
Isochorismatase domain-containing protein 1

1

0

High-throughput

0.279

Low

925678

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.279

Low

925701

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

105630

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

247762

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

925654

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

925662

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

925665

OR2G3
Olfactory receptor 2G3

1

0

High-throughput

0.249

Low

925682

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

48230

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.232

Low

254901

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

261140

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

925649

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

925650

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

925663

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low

925672

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low

925677

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.232

Low

925680

PCGF6
Polycomb group RING finger protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025