HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: LIMA1 (Q9UHB6)
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Gene: LIMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016477 - cell migration GO:0031529 - ruffle organization
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 759
+	Hs
		894559 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		901022 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		925387 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MICA3_HUMAN (271-544): 5.7e-43: 170: 23.93
+	Hs
		564587 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MICA3_HUMAN (271-544): 5.7e-43: 170: 23.93
+	Hs
		1186089 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MICA3_HUMAN (271-544): 5.7e-43: 170: 23.93
+	Hs
		892450 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		MICA3_HUMAN (271-544): 5.7e-43: 170: 23.93
+	Hs
		925433 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MILK1_HUMAN (355-540): 3.05e-31: 133: 21.81
+	Hs
		564610 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MILK1_HUMAN (355-540): 3.05e-31: 133: 21.81
+	Hs
		1232332 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MILK1_HUMAN (355-540): 3.05e-31: 133: 21.81
+	Hs
		892482 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		MILK1_HUMAN (355-540): 3.05e-31: 133: 21.81
+	Hs
		951148 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MILK1_HUMAN (355-540): 3.05e-31: 133: 21.81
+	Hs
		894206 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		MILK1_HUMAN (355-540): 3.05e-31: 133: 21.81
+	Hs
		900682 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		MILK1_HUMAN (355-540): 3.05e-31: 133: 21.81
+	Hs
		857915 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		CRIP2_HUMAN (348-471): 3.86e-29: 117: 27.48
+	Dd
		246627 RAC1A_DICDI (1-192): 5.63e-82: 243: 81.96		LIME_DICDI (386-441): 1.2e-21: 95.3: 42.86
+	Gg
		823526 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		PAXI_CHICK (268-446): 3.73e-14: 78.1: 14.53