HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ASAP1 (Q9ULH1)
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP)
Gene: ASAP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras, PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0043197 - dendritic spine GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1129
+	Hs
		892677 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ASAP1_HUMAN (17-1129): 0: 831: 100.00
+	Hs
		245184 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		OPHN1_HUMAN (44-899): 1.86e-105: 351: 13.82
+	Hs
		925551 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP2_HUMAN (379-660): 2.63e-91: 320: 28.32
+	Hs
		545580 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		AGAP2_HUMAN (379-660): 2.63e-91: 320: 28.32
+	Mm
		892722 CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31		AGAP2_MOUSE (379-660): 1.64e-87: 309: 29.02
+	Hs
		925736 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP1_HUMAN (361-662): 1.75e-62: 231: 28.30
+	Hs
		925478 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARAP2_HUMAN (162-622): 8.31e-61: 230: 18.97
+	Hs
		925529 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARAP1_HUMAN (368-620): 3.83e-58: 222: 24.90
+	Hs
		892516 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ARAP2_HUMAN (162-622): 8.31e-61: 230: 18.97
+	Hs
		925274 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		564527 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		545371 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		1050152 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		892513 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ARAP3_HUMAN (368-605): 4.78e-56: 215: 27.46
+	Hs
		892368 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		950990 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		GIT2_HUMAN (446-1074): 4.12e-57: 213: 16.98
+	Hs
		63073 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG42_HUMAN (760-1124): 2.05e-14: 80.3: 12.02
+	Dm
		776930 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		RHGF_DROME (680-1127): 1.73e-15: 83.7: 11.37
+	Hs
		63065 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RHG42_HUMAN (760-1124): 2.05e-14: 80.3: 12.02
+	Hs
		63072 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		RHG42_HUMAN (760-1124): 2.05e-14: 80.3: 12.02