HitPredict

Interactor 1: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Interactor 2: RHG32 (Q811P8)
Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)
Gene: Arhgap32

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12531901
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0000139 - Golgi membrane GO:0007264 - small GTPase-mediated signal transduction GO:0043197 - dendritic spine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 2089
+	Hs
		64688 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG32_HUMAN (1-2089): 0: 1532: 87.42
+	Hs
		147862 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG33_HUMAN (74-1279): 2.54e-107: 377: 31.90
+	Hs
		925319 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG31_HUMAN (350-1625): 4.56e-86: 314: 23.46
+	Hs
		925242 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG05_HUMAN (25-589): 1.22e-80: 297: 17.57
+	Hs
		302639 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FA13A_HUMAN (335-1088): 9.8e-80: 288: 16.52
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (11-1148): 7.24e-77: 286: 15.68
+	Hs
		63073 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG42_HUMAN (313-861): 2.06e-77: 279: 18.00
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (86-567): 5.05e-81: 278: 18.58
+	Hs
		245184 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		OPHN1_HUMAN (313-774): 6.48e-77: 275: 18.68
+	Hs
		925378 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG27_HUMAN (238-568): 5.55e-76: 275: 27.46
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (184-562): 4.01e-80: 274: 22.60
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (184-562): 3.79e-79: 272: 21.41
+	Hs
		253337 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP2_HUMAN (21-934): 1.48e-70: 261: 13.41
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (289-810): 4.96e-73: 261: 18.37
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (281-562): 5.86e-74: 252: 25.18
+	Hs
		925354 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG17_HUMAN (127-1008): 1.02e-66: 247: 14.17
+	Hs
		925314 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG44_HUMAN (127-976): 2.43e-66: 244: 15.08
+	Mm
		925793 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		ABR_MOUSE (350-569): 6.01e-66: 244: 32.89
+	Hs
		200213 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP3_HUMAN (160-900): 1.66e-64: 243: 13.94
+	Mm
		925798 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		BCR_MOUSE (369-537): 2.01e-17: 91.7: 33.53