HitPredict

Interactor 1: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Interactor 2: PK3CB (Q8BTI9)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1)
Gene: Pik3cb

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	23706742
Identification Methods	pull down, isothermal titration calorimetry
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras, PI3K_rbd~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis and 1 others more... GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 1064
+	Mm
		951511 RHOG_MOUSE (1-192): 3.1e-79: 236: 71.35		PK3CB_MOUSE (1-1064): 0: 1301: 100.00
+	Mm
		892731 CDC42_MOUSE (1-192): 1.4e-78: 234: 70.31		PK3CB_MOUSE (1-1064): 0: 1301: 100.00
+	Hs
		787203 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PK3CA_HUMAN (1-1061): 0: 1060: 39.11
+	Hs
		564440 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PK3CA_HUMAN (1-1061): 0: 1060: 39.11
+	Hs
		787196 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		PK3CA_HUMAN (1-1061): 0: 1060: 39.11
+	Hs
		128803 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		P3C2A_HUMAN (116-1060): 0: 782: 26.23
+	Hs
		128832 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		P3C2A_HUMAN (116-1060): 0: 782: 26.23
+	Hs
		128833 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		P3C2A_HUMAN (116-1060): 0: 782: 26.23
+	Hs
		925325 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		564555 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		545417 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		1117795 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		892405 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		951044 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		894084 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		900539 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		Q4LE69_HUMAN (442-1052): 3.32e-145: 481: 20.80
+	Hs
		893894 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		PRKDC_HUMAN (507-1020): 1.06e-96: 340: 17.67
+	Hs
		900371 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		PRKDC_HUMAN (507-1020): 1.06e-96: 340: 17.67
+	Hs
		893980 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ATR_HUMAN (670-1050): 9.06e-86: 307: 17.16
+	Hs
		900702 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		PK3C3_HUMAN (297-647): 1.49e-74: 266: 20.83