HitPredict

Interactor 1: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Interactor 2: STON2 (Q8WXE9)
Stonin-2 (Stoned B)
Gene: STON2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	34079125, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adap_comp_sub~Adaptin_N
Common GO terms	GO:0005829 - cytosol GO:0030122 - AP-2 adaptor complex GO:0048488 - synaptic vesicle endocytosis GO:0072583 - clathrin-dependent endocytosis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 937 Hs			1 905
+	Hs
		1014058 AP1B1_HUMAN (1-937): 0: 888: 82.72		STON2_HUMAN (1-905): 0: 1331: 100.00
+	Hs
		925992 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP1M1_HUMAN (427-871): 5.22e-153: 458: 19.26
+	Hs
		926066 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP1M2_HUMAN (427-871): 1.11e-148: 447: 19.91
+	Hs
		1014074 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP1M1_HUMAN (427-871): 5.22e-153: 458: 19.26
+	Hs
		1014107 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP1M2_HUMAN (427-871): 1.11e-148: 447: 19.91
+	Hs
		925969 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP2M1_HUMAN (472-871): 2.4e-126: 389: 18.53
+	Hs
		1014061 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP2M1_HUMAN (472-871): 2.4e-126: 389: 18.53
+	Ce
		725358 Q9N4F3_CAEEL (1-935): 0: 770: 62.11		AP1M_CAEEL (436-871): 7.98e-140: 424: 19.26
+	Dm
		248295 Q24253_DROME (1-937): 0: 804: 71.75		O62530_DROME (473-871): 4.43e-121: 376: 18.01
+	At
		187750 APBLC_ARATH (3-936): 0: 756: 56.46		AP2M_ARATH (437-871): 1.2e-130: 401: 17.98
+	At
		187886 APBLB_ARATH (3-936): 0: 750: 56.14		AP2M_ARATH (437-871): 1.2e-130: 401: 17.98
+	Ce
		725366 Q9N4F3_CAEEL (1-935): 0: 770: 62.11		AP2M_CAEEL (473-871): 1.04e-120: 375: 18.78
+	Hs
		321614 AP2A1_HUMAN (11-932): 0: 634: 16.97		AP2M1_HUMAN (472-871): 2.4e-126: 389: 18.53
+	Hs
		302192 AP2A2_HUMAN (11-933): 0: 600: 16.99		AP2M1_HUMAN (472-871): 2.4e-126: 389: 18.53
+	Rn
		577193 AP2A2_RAT (11-932): 0: 595: 16.50		AP2M1_RAT (472-871): 2.4e-126: 389: 18.53
+	At
		187823 AP2A1_ARATH (13-934): 0: 556: 16.10		AP2M_ARATH (437-871): 1.2e-130: 401: 17.98
+	At
		187822 AP2A2_ARATH (13-934): 0: 554: 15.90		AP2M_ARATH (437-871): 1.2e-130: 401: 17.98
+	Dm
		248292 AP2A_DROME (11-931): 0: 573: 16.72		O62530_DROME (473-871): 4.43e-121: 376: 18.01
+	Hs
		120050 AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17		AP3M1_HUMAN (450-873): 5.23e-105: 333: 14.13
+	Hs
		119937 AP3B1_HUMAN (8-594): 5.76e-178: 547: 28.17		AP3M2_HUMAN (450-873): 2.47e-99: 318: 14.57