Protein: TCP4
Activated RNA polymerase II transcriptional coactivator p15 (Positive cofactor 4) (PC4) (SUB1 homolog) (p14)

Gene: TCP4, SUB1
Organism: Homo sapiens
Interactions: 190
UniProt ID: P53999

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001111 - RNA polymerase II promoter clearance
GO:0003697 - single-stranded DNA binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925888

TCP4
Activated RNA polymerase II transcriptional coactivator p15

5

6

Small-scale

0.922

High

925898

CSK21
Casein kinase II subunit alpha

2

1

Small-scale

0.611

High

464885

SP1
Transcription factor Sp1

2

1

Small-scale

0.595

High

750399

CSTF2
Cleavage stimulation factor subunit 2

1

1

Small-scale

0.586

High

925895

RL11
Large ribosomal subunit protein uL5

2

0

Small-scale

0.585

High

325750

UBR5
E3 ubiquitin-protein ligase UBR5

2

3

Small-scale

0.584

High

667677

CDK2
Cyclin-dependent kinase 2

2

3

High-throughput

0.584

High

140194

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

413469

P53
Cellular tumor antigen p53

1

1

Small-scale

0.578

High

925908

EP300
Histone acetyltransferase p300

2

0

Small-scale

0.577

High

830406

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

791214

SYUA
Alpha-synuclein

2

0

High-throughput

0.547

High

925913

REST
RE1-silencing transcription factor

1

0

Small-scale

0.537

High

925963

OTUD5
OTU domain-containing protein 5

1

0

Small-scale

0.537

High

925993

RCOR1
REST corepressor 1

1

0

Small-scale

0.537

High

172611

XPO1
Exportin-1

1

2

High-throughput

0.536

High

210181

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

783541

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

908348

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.536

High

925904

KPCZ
Protein kinase C zeta type

1

1

High-throughput

0.536

High

925906

SSRP1
FACT complex subunit SSRP1

1

3

High-throughput

0.536

High

925917

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

3

High-throughput

0.536

High

925923

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

925931

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

925949

MINK1
Misshapen-like kinase 1

1

1

High-throughput

0.536

High

925966

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

1

High-throughput

0.536

High

925970

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

925976

SLK
STE20-like serine/threonine-protein kinase

1

1

High-throughput

0.536

High

925991

KS6B2
Ribosomal protein S6 kinase beta-2

1

1

High-throughput

0.536

High

213873

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

257790

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

High-throughput

0.513

High

300972

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.513

High

352373

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.513

High

362222

ABL1
Tyrosine-protein kinase ABL1

1

0

High-throughput

0.513

High

389180

FINC
Fibronectin

1

0

High-throughput

0.513

High

431035

LA
Lupus La protein

1

0

High-throughput

0.513

High

484449

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

563473

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

576326

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.513

High

578646

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

842698

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.513

High

859157

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

890428

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.513

High

902257

RB27A
Ras-related protein Rab-27A

1

0

High-throughput

0.513

High

925905

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.513

High

925910

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.513

High

925914

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

High-throughput

0.513

High

925921

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.513

High

925929

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.513

High

925941

COMD6
COMM domain-containing protein 6

1

0

High-throughput

0.513

High

925951

COMD1
COMM domain-containing protein 1

1

0

High-throughput

0.513

High

925955

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.513

High

925967

TRIB3
Tribbles homolog 3

1

0

High-throughput

0.513

High

925971

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.513

High

925973

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

925975

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

925979

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.513

High

925982

NOP10
H/ACA ribonucleoprotein complex subunit 3

1

0

High-throughput

0.513

High

925984

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

925988

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

0

High-throughput

0.513

High

283050

PSIP1
PC4 and SFRS1-interacting protein

1

2

Small-scale

0.501

High

833903

HNF4A
Hepatocyte nuclear factor 4-alpha

1

1

Small-scale

0.501

High

925919

AAMP
Angio-associated migratory cell protein

1

2

High-throughput

0.489

High

421781

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

667231

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.480

High

722921

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.480

High

853203

CBX5
Chromobox protein homolog 5

1

0

Small-scale

0.480

High

925930

OBF1
POU domain class 2-associating factor 1

1

0

Small-scale

0.480

High

323255

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

355461

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

Small-scale

0.479

High

371555

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

405938

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

533907

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

606491

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

730465

1433S
14-3-3 protein sigma

1

2

Small-scale

0.479

High

861945

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

878831

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

897178

CDK7
Cyclin-dependent kinase 7

1

3

High-throughput

0.479

High

925890

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

925892

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

925894

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

925901

CDK5
Cyclin-dependent kinase 5

1

3

High-throughput

0.479

High

925902

SP3
Transcription factor Sp3

1

1

Small-scale

0.479

High

925903

1433F
14-3-3 protein eta

1

2

High-throughput

0.479

High

925912

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

925925

IRF4
Interferon regulatory factor 4

1

1

Small-scale

0.479

High

925927

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

925932

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

925942

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

925957

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

925959

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.479

High

925960

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

925965

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

Small-scale

0.479

High

925974

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

925978

CLK4
Dual specificity protein kinase CLK4

1

1

High-throughput

0.479

High

925980

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

140823

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

254343

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.458

High

259675

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

280406

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

0

Small-scale

0.458

High

285619

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

319561

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

363023

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

446799

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

482381

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

487126

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

532476

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

536818

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

557981

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

583233

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

588292

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

615505

NELFE
Negative elongation factor E

1

0

High-throughput

0.458

High

695019

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

767781

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

837483

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

887860

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

904496

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

925891

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

925893

H4
Histone H4

1

0

High-throughput

0.458

High

925896

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.458

High

925897

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

925899

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

925900

H33
Histone H3.3

1

0

High-throughput

0.458

High

925909

TF3C1
General transcription factor 3C polypeptide 1

1

0

Small-scale

0.458

High

925911

FOXC1
Forkhead box protein C1

1

0

High-throughput

0.458

High

925918

CUL3
Cullin-3

1

0

High-throughput

0.458

High

925924

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

925926

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.458

High

925928

SEPT7
Septin-7

1

0

High-throughput

0.458

High

925934

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.458

High

925935

TEN4
Teneurin-4

1

0

High-throughput

0.458

High

925943

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

925944

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

925947

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

925954

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

925956

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

925958

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.458

High

925961

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

925962

OPTN
Optineurin

1

0

High-throughput

0.458

High

925964

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

925968

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

925969

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.458

High

925972

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

925985

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

925987

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

925994

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.458

High

925995

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

925996

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.458

High

925998

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

587032

ITF2
Transcription factor 4

1

1

High-throughput

0.445

High

925953

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.437

High

529409

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

765285

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

925907

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

925916

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

925920

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

925939

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

925936

Q6NSK7
RIN3 protein

1

2

High-throughput

0.417

High

886671

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

354612

PAK4
Serine/threonine-protein kinase PAK 4

2

0

High-throughput

0.313

High

925990

RHG20
Rho GTPase-activating protein 20

2

0

High-throughput

0.298

High

135556

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.279

Low

925933

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.279

Low

925945

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

925946

MYLK4
Myosin light chain kinase family member 4

1

0

High-throughput

0.279

Low

925948

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

925981

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.279

Low

925986

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.279

Low

925989

PIM2
Serine/threonine-protein kinase pim-2

1

0

High-throughput

0.279

Low

925915

PTK7
Inactive tyrosine-protein kinase 7

1

0

High-throughput

0.269

Low

701784

ABCD3
ATP-binding cassette sub-family D member 3

1

0

High-throughput

0.268

Low

925938

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

116812

GOG8R
Golgin subfamily A member 8R

1

0

High-throughput

0.249

Low

131370

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

Small-scale

0.249

Low

318678

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

418036

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

590844

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

925889

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.249

Low

925922

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

925937

SCYL2
SCY1-like protein 2

1

0

High-throughput

0.249

Low

925940

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

925950

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

925952

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

925983

STAR7
StAR-related lipid transfer protein 7, mitochondrial

1

0

High-throughput

0.249

Low

925992

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low

925997

SHLB1
Endophilin-B1

1

0

High-throughput

0.249

Low

271456

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.232

Low

284555

ECI2
Enoyl-CoA delta isomerase 2

1

0

High-throughput

0.232

Low

925977

GHC1
Mitochondrial glutamate carrier 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025