HitPredict

Interactor 1: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Interactor 2: AP1S3 (Q96PC3)
AP-1 complex subunit sigma-3 (Adaptor protein complex AP-1 subunit sigma-1C) (Adaptor-related protein complex 1 subunit sigma-1C) (Clathrin assembly protein complex 1 sigma-1C small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1C subunit) (Sigma 1C subunit of AP-1 clathrin) (Sigma-adaptin 1C) (Sigma1C-adaptin)
Gene: AP1S3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0016192 - vesicle-mediated transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 937 Hs			1 154
+	Hs
		880408 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP1S2_HUMAN (2-154): 1.83e-54: 170: 71.24
+	Hs
		903681 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP1S1_HUMAN (1-154): 1.51e-54: 170: 67.53
+	Hs
		925992 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP1M1_HUMAN (3-146): 8.38e-45: 153: 19.44
+	Hs
		926066 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP1M2_HUMAN (3-147): 9.28e-43: 148: 17.93
+	Hs
		864065 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP2S1_HUMAN (1-142): 2.1e-45: 146: 42.96
+	Hs
		925969 AP2B1_HUMAN (1-937): 0: 926: 100.00		AP2M1_HUMAN (1-153): 5.51e-42: 146: 17.50
+	Hs
		880409 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP1S2_HUMAN (2-154): 1.83e-54: 170: 71.24
+	Hs
		903682 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP1S1_HUMAN (1-154): 1.51e-54: 170: 67.53
+	Hs
		1014066 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP1S3_HUMAN (1-154): 1.61e-53: 167: 100.00
+	Hs
		1014074 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP1M1_HUMAN (3-146): 8.38e-45: 153: 19.44
+	Hs
		1014107 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP1M2_HUMAN (3-147): 9.28e-43: 148: 17.93
+	Hs
		1014061 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP2M1_HUMAN (1-153): 5.51e-42: 146: 17.50
+	Hs
		864070 AP1B1_HUMAN (1-937): 0: 888: 82.72		AP2S1_HUMAN (1-142): 2.1e-45: 146: 42.96
+	Dm
		248295 Q24253_DROME (1-937): 0: 804: 71.75		O62530_DROME (1-154): 5.52e-44: 151: 18.18
+	Dm
		1096906 Q24253_DROME (1-937): 0: 804: 71.75		Q9VDC3_DROME (1-142): 2.79e-46: 149: 43.66
+	Ce
		725366 Q9N4F3_CAEEL (1-935): 0: 770: 62.11		AP2M_CAEEL (1-153): 1.56e-43: 150: 18.29
+	Ce
		725358 Q9N4F3_CAEEL (1-935): 0: 770: 62.11		AP1M_CAEEL (3-141): 4e-42: 146: 19.42
+	At
		1196570 APBLB_ARATH (3-936): 0: 750: 56.14		AP2S_ARATH (1-142): 7.55e-45: 145: 46.48
+	Zm
		30064 A0A1D6K3D9_MAIZE (41-936): 0: 711: 55.28		Q9MAY9_MAIZE (2-151): 1.48e-43: 143: 19.48
+	Hs
		321516 AP2A1_HUMAN (11-932): 0: 634: 16.97		AP2S1_HUMAN (1-142): 2.1e-45: 146: 42.96