HitPredict

Interactor 1: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Interactor 2: PTPRR (Q62132)
Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Phosphotyrosine phosphatase 13) (Protein-tyrosine-phosphatase SL)
Gene: PTPRR

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.674

Property	Details
Experiments	9857190, 10419510, 16148006
Identification Methods	pull down, protein kinase assay, phosphatase assay, two hybrid
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Mm			1 656
+	Hs
		658952 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PTPRR_HUMAN (1-656): 0: 1029: 89.19
+	Hs
		647583 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRR_HUMAN (1-656): 0: 1029: 89.19
+	Hs
		1026853 MK07_HUMAN (9-356): 3.39e-140: 419: 49.15		PTPRR_HUMAN (1-656): 0: 1029: 89.19
+	Hs
		658867 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PTN5_HUMAN (222-656): 0: 548: 49.43
+	Hs
		647525 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTN5_HUMAN (222-656): 0: 548: 49.43
+	Mm
		873169 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		PTN5_MOUSE (222-656): 0: 532: 48.98
+	Hs
		658812 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PTN7_HUMAN (309-655): 1e-142: 421: 53.03
+	Hs
		647484 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTN7_HUMAN (309-655): 1e-142: 421: 53.03
+	Hs
		616902 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PTPRB_HUMAN (329-656): 8.12e-119: 392: 31.55
+	Hs
		616900 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRB_HUMAN (329-656): 8.12e-119: 392: 31.55
+	Hs
		658916 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PTPRJ_HUMAN (383-644): 3.17e-108: 357: 37.69
+	Hs
		647561 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRJ_HUMAN (383-644): 3.17e-108: 357: 37.69
+	Hs
		617041 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PTPRE_HUMAN (391-647): 1.44e-92: 303: 32.71
+	Hs
		617037 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRE_HUMAN (391-647): 1.44e-92: 303: 32.71
+	Hs
		441182 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PTPRC_HUMAN (377-644): 2.31e-72: 256: 28.43
+	Hs
		441180 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRC_HUMAN (377-644): 2.31e-72: 256: 28.43
+	Hs
		647584 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRK_HUMAN (384-648): 2.66e-59: 218: 30.22
+	Hs
		617077 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRG_HUMAN (364-649): 1.22e-50: 192: 24.51
+	Hs
		647596 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		PTPRO_HUMAN (410-645): 2.39e-48: 185: 42.32
+	Hs
		441200 MK14_HUMAN (16-354): 1.6e-111: 330: 48.97		PTPRC_HUMAN (377-644): 2.31e-72: 256: 28.43