Protein: TDRD3
Tudor domain-containing protein 3

Gene: TDRD3
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q9H7E2

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

352551

TOP3B
DNA topoisomerase 3-beta-1

8

4

Small-scale

0.973

High

1056977

FMR1
Fragile X messenger ribonucleoprotein 1

5

6

Small-scale

0.716

High

900162

FXR1
RNA-binding protein FXR1

5

6

Small-scale

0.711

High

1106456

TOP3A
DNA topoisomerase 3-alpha

1

4

Small-scale

0.710

High

900513

FXR2
RNA-binding protein FXR2

3

6

Small-scale

0.646

High

667456

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

Small-scale

0.618

High

875782

PRC2A
Protein PRRC2A

2

3

High-throughput

0.611

High

1393954

FUBP3
Far upstream element-binding protein 3

2

2

High-throughput

0.611

High

508637

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

1

Small-scale

0.602

High

775316

FUS
RNA-binding protein FUS

2

3

Small-scale

0.586

High

1435681

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.586

High

141662

DDX3X
ATP-dependent RNA helicase DDX3X

2

1

Small-scale

0.584

High

346336

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

550468

PABP1
Polyadenylate-binding protein 1

2

1

Small-scale

0.584

High

1087554

GRSF1
G-rich sequence factor 1

2

2

High-throughput

0.584

High

1122163

UBP2L
Ubiquitin-associated protein 2-like

2

1

High-throughput

0.584

High

1215833

RC3H1
Roquin-1

2

1

High-throughput

0.584

High

1310649

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

2

High-throughput

0.584

High

1334926

SERB1
SERPINE1 mRNA-binding protein 1

2

1

Small-scale

0.584

High

1435724

RBM8A
RNA-binding protein 8A

2

2

Small-scale

0.584

High

396957

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1062650

DHX9
ATP-dependent RNA helicase A

1

3

Small-scale

0.561

High

644060

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.559

High

961110

MGN
Protein mago nashi homolog

2

0

Small-scale

0.559

High

1123821

DCTN1
Dynactin subunit 1

2

0

High-throughput

0.559

High

1340620

TDRD7
Tudor domain-containing protein 7

1

1

High-throughput

0.553

High

1371535

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

0

Small-scale

0.537

High

553072

PIP
Prolactin-inducible protein

1

1

High-throughput

0.536

High

1093183

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.536

High

1145375

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.536

High

443101

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.513

High

447453

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

1244968

FIGL1
Fidgetin-like protein 1

1

0

High-throughput

0.513

High

1390972

THOC1
THO complex subunit 1

1

0

High-throughput

0.513

High

1372307

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.493

High

1349434

POC1B
POC1 centriolar protein homolog B

1

1

High-throughput

0.489

High

48074

RBM47
RNA-binding protein 47

1

2

High-throughput

0.479

High

50419

MEX3A
RNA-binding protein MEX3A

1

4

High-throughput

0.479

High

124967

GTPB1
GTP-binding protein 1

1

2

High-throughput

0.479

High

183517

CASC3
Protein CASC3

1

1

High-throughput

0.479

High

213489

CTIF
CBP80/20-dependent translation initiation factor

1

1

High-throughput

0.479

High

250833

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.479

High

273931

CNOT3
CCR4-NOT transcription complex subunit 3

1

2

High-throughput

0.479

High

274237

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.479

High

684392

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.479

High

688314

TTP
mRNA decay activator protein ZFP36

1

1

High-throughput

0.479

High

713853

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

2

High-throughput

0.479

High

726801

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

1

High-throughput

0.479

High

731622

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

807584

IF4A3
Eukaryotic initiation factor 4A-III

1

4

High-throughput

0.479

High

891315

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

891793

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

895965

F10A1
Hsc70-interacting protein

1

1

High-throughput

0.479

High

954001

IF4A1
Eukaryotic initiation factor 4A-I

1

3

High-throughput

0.479

High

1024849

VIGLN
Vigilin

1

3

High-throughput

0.479

High

1032414

OTUD4
OTU domain-containing protein 4

1

1

High-throughput

0.479

High

1033231

EWS
RNA-binding protein EWS

1

1

Small-scale

0.479

High

1099036

SRSF9
Serine/arginine-rich splicing factor 9

1

1

High-throughput

0.479

High

1101029

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

1108160

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1124306

IF4A2
Eukaryotic initiation factor 4A-II

1

3

High-throughput

0.479

High

1125230

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

1131127

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.479

High

1138951

R3HD1
R3H domain-containing protein 1

1

2

High-throughput

0.479

High

1152247

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.479

High

1152638

ELAV1
ELAV-like protein 1

1

1

High-throughput

0.479

High

1165505

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

1

High-throughput

0.479

High

1199377

GLE1
mRNA export factor GLE1

1

1

High-throughput

0.479

High

1206546

PRC2B
Protein PRRC2B

1

2

High-throughput

0.479

High

1217505

CE350
Centrosome-associated protein 350

1

1

High-throughput

0.479

High

1220804

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1240494

DHX57
Putative ATP-dependent RNA helicase DHX57

1

3

High-throughput

0.479

High

1252387

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1271553

DHX30
ATP-dependent RNA helicase DHX30

1

3

High-throughput

0.479

High

1275677

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

High-throughput

0.479

High

1280740

YTHD3
YTH domain-containing family protein 3

1

2

High-throughput

0.479

High

1287127

PATL1
Protein PAT1 homolog 1

1

1

High-throughput

0.479

High

1288979

EST1A
Telomerase-binding protein EST1A

1

2

High-throughput

0.479

High

1294569

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

High-throughput

0.479

High

1295562

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

High-throughput

0.479

High

1311405

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

1

High-throughput

0.479

High

1325009

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

1

High-throughput

0.479

High

1336298

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.479

High

1349695

CIP2A
Protein CIP2A

1

1

High-throughput

0.479

High

1363327

DDX1
ATP-dependent RNA helicase DDX1

1

2

High-throughput

0.479

High

1363978

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

2

High-throughput

0.479

High

1365671

LAR4B
La-related protein 4B

1

2

High-throughput

0.479

High

1367285

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1369842

CELF1
CUGBP Elav-like family member 1

1

2

High-throughput

0.479

High

1370112

RENT1
Regulator of nonsense transcripts 1

1

2

High-throughput

0.479

High

1370243

DAZL
Deleted in azoospermia-like

1

3

High-throughput

0.479

High

1387726

TBC31
TBC1 domain family member 31

1

2

High-throughput

0.479

High

1405859

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1406492

ATX2
Ataxin-2

1

1

High-throughput

0.479

High

1407879

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1412093

TRI56
E3 ubiquitin-protein ligase TRIM56

1

2

High-throughput

0.479

High

1416465

LS14B
Protein LSM14 homolog B

1

1

High-throughput

0.479

High

1418729

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.479

High

1420664

UNK
RING finger protein unkempt homolog

1

2

High-throughput

0.479

High

1429460

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

1

High-throughput

0.479

High

1434744

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.479

High

1435682

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

1435683

MOV10
Helicase MOV-10

1

2

High-throughput

0.479

High

1435686

TRI36
E3 ubiquitin-protein ligase TRIM36

1

1

High-throughput

0.479

High

1435688

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

1

High-throughput

0.479

High

1435689

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.479

High

1435690

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

1

High-throughput

0.479

High

1435691

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.479

High

1435693

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1435694

CNOT2
CCR4-NOT transcription complex subunit 2

1

1

High-throughput

0.479

High

1435696

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

High-throughput

0.479

High

1435700

AGO2
Protein argonaute-2

1

2

High-throughput

0.479

High

1435701

AGO1
Protein argonaute-1

1

2

High-throughput

0.479

High

1435704

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.479

High

1435709

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

High-throughput

0.479

High

1435714

R3HD2
R3H domain-containing protein 2

1

3

High-throughput

0.479

High

1435715

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

High-throughput

0.479

High

1435716

STRAP
Serine-threonine kinase receptor-associated protein

1

2

High-throughput

0.479

High

1435722

PRC2C
Protein PRRC2C

1

2

High-throughput

0.479

High

1435723

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

1435725

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

3

High-throughput

0.479

High

64120

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

136000

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.458

High

175211

SC16A
Protein transport protein Sec16A

1

0

High-throughput

0.458

High

176548

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

286286

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.458

High

290155

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

347331

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

349241

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

459757

PROF1
Profilin-1

1

0

High-throughput

0.458

High

485418

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

582963

EZRI
Ezrin

1

0

High-throughput

0.458

High

679259

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.458

High

775722

DEK
Protein DEK

1

0

High-throughput

0.458

High

946203

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

954273

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

982830

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

996339

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.458

High

1093314

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.458

High

1126538

CAPR1
Caprin-1

1

0

High-throughput

0.458

High

1129506

PUM1
Pumilio homolog 1

1

0

High-throughput

0.458

High

1156598

CCDC6
Coiled-coil domain-containing protein 6

1

0

High-throughput

0.458

High

1156860

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1169035

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.458

High

1178015

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1187080

LSM12
Protein LSM12

1

0

High-throughput

0.458

High

1208578

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

1277937

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1289197

N4BP2
NEDD4-binding protein 2

1

0

High-throughput

0.458

High

1289635

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1291360

LCA5
Lebercilin

1

0

High-throughput

0.458

High

1316457

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

1331966

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

0

High-throughput

0.458

High

1335321

FA98A
Protein FAM98A

1

0

High-throughput

0.458

High

1356324

SMAP2
Stromal membrane-associated protein 2

1

0

High-throughput

0.458

High

1357561

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1358109

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1361160

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.458

High

1365359

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1400481

SMG1
Serine/threonine-protein kinase SMG1

1

0

High-throughput

0.458

High

1403243

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.458

High

1405214

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.458

High

1406572

METH
Methionine synthase

1

0

High-throughput

0.458

High

1429224

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

0

High-throughput

0.458

High

1431539

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1435687

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.458

High

1435692

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1435695

CEP72
Centrosomal protein of 72 kDa

1

0

High-throughput

0.458

High

1435697

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.458

High

1435698

ZO2
Tight junction protein 2

1

0

High-throughput

0.458

High

1435699

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.458

High

1435703

UBQL1
Ubiquilin-1

1

0

High-throughput

0.458

High

1435705

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.458

High

1435706

CC14A
Dual specificity protein phosphatase CDC14A

1

0

High-throughput

0.458

High

1435707

CP131
Centrosomal protein of 131 kDa

1

0

High-throughput

0.458

High

1435708

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

1435711

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.458

High

1435712

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

1435713

NINL
Ninein-like protein

1

0

High-throughput

0.458

High

1435717

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.458

High

1435718

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

1435719

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.458

High

1435720

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

1435721

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.458

High

1334176

POC1A
POC1 centriolar protein homolog A

1

1

High-throughput

0.437

High

1435685

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

1

High-throughput

0.437

High

1435702

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

1435710

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.437

High

765894

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

994798

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.426

High

1162045

H31T
Histone H3.1t

1

0

Small-scale

0.391

High

963228

LYSC
Lysozyme C

1

0

High-throughput

0.279

Low

246139

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.249

Low

1130023

KCTD2
BTB/POZ domain-containing protein KCTD2

1

0

High-throughput

0.249

Low

1193479

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.249

Low

1206148

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.249

Low

1241348

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

1286747

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.249

Low

1332512

POC5
Centrosomal protein POC5

1

0

High-throughput

0.249

Low

1397839

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

1409766

PAIP2
Polyadenylate-binding protein-interacting protein 2

1

0

High-throughput

0.249

Low

1411047

CCD77
Coiled-coil domain-containing protein 77

1

0

High-throughput

0.249

Low

1433900

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1435684

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025