HitPredict

Interactor 1: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Interactor 2: MKNK2 (Q8CDB0)
MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)
Gene: MKNK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	9155017, 15102471
Identification Methods	in-gel kinase assay, two hybrid
Interaction Type	phosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0035556 - intracellular signal transduction and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Mm			1 459
+	Hs
		659061 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		MKNK2_HUMAN (1-459): 4.77e-152: 442: 92.26
+	Mm
		1144379 MK03_MOUSE (13-355): 3.86e-153: 437: 88.34		MKNK2_MOUSE (1-459): 4.29e-156: 452: 100.00
+	Hs
		647686 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		MKNK2_HUMAN (1-459): 4.77e-152: 442: 92.26
+	Hs
		659040 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		MKNK1_HUMAN (38-451): 1.46e-141: 415: 63.74
+	Hs
		647670 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		MKNK1_HUMAN (38-451): 1.46e-141: 415: 63.74
+	Mm
		139597 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		MKNK1_MOUSE (39-450): 1.55e-136: 401: 71.85
+	Mm
		139598 MK03_MOUSE (13-355): 3.86e-153: 437: 88.34		MKNK1_MOUSE (39-450): 1.55e-136: 401: 71.85
+	Mm
		578259 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		KS6A3_MOUSE (89-360): 8.2e-23: 103: 29.96
+	Hs
		658953 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		KS6A2_HUMAN (89-367): 8.03e-24: 106: 30.21
+	Hs
		659084 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		KS6A6_HUMAN (89-362): 8.92e-24: 106: 30.11
+	Hs
		658860 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		KS6A3_HUMAN (89-360): 8.43e-23: 103: 29.96
+	Xl
		499136 MK01_XENLA (1-356): 1.44e-157: 447: 95.01		KS6AA_XENLA (89-360): 7.85e-23: 103: 31.41
+	Hs
		270374 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		KS6A5_HUMAN (89-375): 6.22e-25: 110: 29.33
+	Hs
		658954 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		KS6A1_HUMAN (89-360): 2.32e-21: 99: 29.96
+	Hs
		647585 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		KS6A2_HUMAN (89-367): 8.03e-24: 106: 30.21
+	Hs
		647706 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		KS6A6_HUMAN (89-362): 8.92e-24: 106: 30.11
+	Hs
		647522 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		KS6A3_HUMAN (89-360): 8.43e-23: 103: 29.96
+	Mm
		578264 MK03_MOUSE (13-355): 3.86e-153: 437: 88.34		KS6A3_MOUSE (89-360): 8.2e-23: 103: 29.96
+	Rn
		88491 MK03_RAT (13-355): 4.12e-153: 437: 88.34		D3Z8E0_RAT (89-360): 8.28e-23: 103: 29.96
+	Hs
		647587 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		KS6A1_HUMAN (89-360): 2.32e-21: 99: 29.96