HitPredict

Interactor 1: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Interactor 2: DUS3 (Q9D7X3)
Dual specificity protein phosphatase 3 (EC 3.1.3.16) (EC 3.1.3.48) (T-DSP11) (Vaccinia H1-related phosphatase) (VHR)
Gene: Dusp3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18035061
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DSPc~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Mm			1 185
+	Hs
		658858 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS3_HUMAN (1-184): 3.22e-71: 215: 93.48
+	Hs
		647521 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DUS3_HUMAN (1-184): 3.22e-71: 215: 93.48
+	Hs
		659043 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS16_HUMAN (1-184): 2.61e-58: 194: 25.26
+	Hs
		658798 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS1_HUMAN (1-182): 3.34e-59: 190: 25.12
+	Hs
		658919 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS4_HUMAN (1-182): 4.62e-59: 190: 25.60
+	Hs
		658923 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS8_HUMAN (1-184): 1.9e-56: 189: 24.62
+	Hs
		658960 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS5_HUMAN (1-181): 3.53e-58: 188: 25.60
+	Hs
		658903 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS2_HUMAN (1-180): 2.51e-58: 186: 28.43
+	Hs
		658962 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS7_HUMAN (17-181): 1.59e-56: 185: 32.53
+	Mm
		926403 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		DUS2_MOUSE (1-180): 1.45e-56: 182: 28.43
+	Hs
		659102 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS10_HUMAN (7-177): 1.09e-55: 184: 31.52
+	Mm
		926439 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		DUS6_MOUSE (17-181): 2.95e-55: 180: 30.72
+	Rn
		926496 MK01_RAT (1-358): 3.67e-159: 451: 100.00		DUS6_RAT (17-181): 2.89e-55: 180: 30.72
+	Hs
		647475 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DUS1_HUMAN (1-182): 3.34e-59: 190: 25.12
+	Hs
		658961 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS6_HUMAN (17-181): 2.01e-55: 181: 30.72
+	Hs
		659081 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DS13B_HUMAN (9-182): 9.52e-58: 181: 41.95
+	Hs
		659034 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS9_HUMAN (18-181): 5.32e-55: 180: 31.36
+	Hs
		647553 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DUS2_HUMAN (1-180): 2.51e-58: 186: 28.43
+	Hs
		659008 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		STYX_HUMAN (6-185): 2.39e-53: 171: 26.23
+	Hs
		659006 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS19_HUMAN (33-182): 3.06e-19: 83.2: 36.42