Protein: ASF1A
Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)

Gene: ASF1A
Organism: Homo sapiens
Interactions: 205
UniProt ID: Q9Y294

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001649 - osteoblast differentiation
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998963

H31
Histone H3.1

19

19

Small-scale

0.987

High

980565

H4
Histone H4

13

5

Small-scale

0.985

High

881113

NASP
Nuclear autoantigenic sperm protein

9

2

Small-scale

0.974

High

888403

MCM2
DNA replication licensing factor MCM2

9

11

Small-scale

0.974

High

1017314

H33
Histone H3.3

9

19

Small-scale

0.972

High

1450753

ASF1B
Histone chaperone ASF1B

4

1

Small-scale

0.895

High

1162086

H31T
Histone H3.1t

2

19

Small-scale

0.806

High

926699

HIRA
Protein HIRA

14

17

Small-scale

0.763

High

1288396

TLK2
Serine/threonine-protein kinase tousled-like 2

8

6

Small-scale

0.754

High

1446359

UBN1
Ubinuclein-1

8

5

Small-scale

0.750

High

1461098

TLK1
Serine/threonine-protein kinase tousled-like 1

7

7

Small-scale

0.750

High

1311326

CDAN1
Codanin-1

6

4

Small-scale

0.742

High

1159054

RBBP7
Histone-binding protein RBBP7

6

5

Small-scale

0.738

High

1066553

RBBP4
Histone-binding protein RBBP4

6

5

Small-scale

0.736

High

1490621

CABIN
Calcineurin-binding protein cabin-1

6

3

Small-scale

0.736

High

1392832

TONSL
Tonsoku-like protein

6

1

Small-scale

0.733

High

1217231

RIF1
Telomere-associated protein RIF1

5

4

High-throughput

0.722

High

1256490

UBN2
Ubinuclein-2

5

6

High-throughput

0.722

High

639852

TAF1
Transcription initiation factor TFIID subunit 1

1

10

Small-scale

0.710

High

1094831

CAF1B
Chromatin assembly factor 1 subunit B

4

14

Small-scale

0.709

High

168344

HAT1
Histone acetyltransferase type B catalytic subunit

4

2

High-throughput

0.704

High

1490617

CDIN1
CDAN1-interacting nuclease 1

4

2

High-throughput

0.704

High

1353385

IPO4
Importin-4

4

3

Small-scale

0.699

High

755824

MCM4
DNA replication licensing factor MCM4

3

10

Small-scale

0.667

High

756413

MCM7
DNA replication licensing factor MCM7

3

10

Small-scale

0.667

High

1128316

MCM6
DNA replication licensing factor MCM6

3

11

Small-scale

0.667

High

1201706

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

3

1

High-throughput

0.667

High

1094753

CAF1A
Chromatin assembly factor 1 subunit A

3

5

Small-scale

0.660

High

1258986

H32
Histone H3.2

1

19

Small-scale

0.646

High

397258

ESR1
Estrogen receptor

3

0

Small-scale

0.630

High

1197603

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

2

1

High-throughput

0.628

High

180966

TIF1A
Transcription intermediary factor 1-alpha

1

3

High-throughput

0.618

High

674380

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.618

High

903524

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

11

Small-scale

0.618

High

1462503

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.618

High

1341202

PPTC7
Protein phosphatase PTC7 homolog

2

1

High-throughput

0.574

High

370376

CYTA
Cystatin-A

1

1

High-throughput

0.536

High

451594

CENPB
Major centromere autoantigen B

1

2

High-throughput

0.536

High

968045

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.536

High

968492

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

1

High-throughput

0.536

High

1030506

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.536

High

1116149

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

143337

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

154774

ARI1A
AT-rich interactive domain-containing protein 1A

1

4

High-throughput

0.479

High

161528

KMT2D
Histone-lysine N-methyltransferase 2D

1

6

High-throughput

0.479

High

177483

ZN536
Zinc finger protein 536

1

1

High-throughput

0.479

High

186823

P73
Tumor protein p73

1

2

High-throughput

0.479

High

256706

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

1

High-throughput

0.479

High

272849

PHF2
Lysine-specific demethylase PHF2

1

1

High-throughput

0.479

High

278454

NCOR1
Nuclear receptor corepressor 1

1

3

High-throughput

0.479

High

316180

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

317045

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.479

High

320366

PHF14
PHD finger protein 14

1

1

High-throughput

0.479

High

345025

WIZ
Protein Wiz

1

1

High-throughput

0.479

High

414880

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

474387

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.479

High

569151

T2FB
General transcription factor IIF subunit 2

1

1

High-throughput

0.479

High

776268

SOX6
Transcription factor SOX-6

1

2

High-throughput

0.479

High

905517

HCFC1
Host cell factor 1

1

1

High-throughput

0.479

High

926438

BLM
RecQ-like DNA helicase BLM

1

1

High-throughput

0.479

High

936582

AF17
Protein AF-17

1

1

High-throughput

0.479

High

1036006

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

1041626

KMT2A
Histone-lysine N-methyltransferase 2A

1

5

High-throughput

0.479

High

1041870

CENPC
Centromere protein C

1

1

High-throughput

0.479

High

1045928

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1086729

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

1088110

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

1102691

MTA1
Metastasis-associated protein MTA1

1

1

High-throughput

0.479

High

1107350

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1129790

MDC1
Mediator of DNA damage checkpoint protein 1

1

4

Small-scale

0.479

High

1130611

NCOA6
Nuclear receptor coactivator 6

1

8

High-throughput

0.479

High

1132652

KIF22
Kinesin-like protein KIF22

1

2

High-throughput

0.479

High

1133282

ARI5B
AT-rich interactive domain-containing protein 5B

1

4

High-throughput

0.479

High

1134772

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.479

High

1138180

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1204644

BCORL
BCL-6 corepressor-like protein 1

1

4

High-throughput

0.479

High

1211573

ZN362
Zinc finger protein 362

1

1

High-throughput

0.479

High

1212057

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

3

High-throughput

0.479

High

1218969

TASO2
Protein TASOR 2

1

4

High-throughput

0.479

High

1228294

ARID2
AT-rich interactive domain-containing protein 2

1

6

High-throughput

0.479

High

1228615

SPT2
Protein SPT2 homolog

1

1

High-throughput

0.479

High

1242509

NFRKB
Nuclear factor related to kappa-B-binding protein

1

6

High-throughput

0.479

High

1248099

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.479

High

1250695

BCOR
BCL-6 corepressor

1

3

High-throughput

0.479

High

1253831

MMS22
Protein MMS22-like

1

1

High-throughput

0.479

High

1253887

SRCAP
Helicase SRCAP

1

11

High-throughput

0.479

High

1278987

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

7

High-throughput

0.479

High

1279184

RAI1
Retinoic acid-induced protein 1

1

5

High-throughput

0.479

High

1279316

I2BP2
Interferon regulatory factor 2-binding protein 2

1

2

High-throughput

0.479

High

1294901

KI18B
Kinesin-like protein KIF18B

1

1

High-throughput

0.479

High

1295329

P66A
Transcriptional repressor p66-alpha

1

1

High-throughput

0.479

High

1323553

ZN687
Zinc finger protein 687

1

1

High-throughput

0.479

High

1328610

MS3L1
MSL complex subunit 3

1

1

High-throughput

0.479

High

1338783

ARI1B
AT-rich interactive domain-containing protein 1B

1

5

High-throughput

0.479

High

1341050

THOC2
THO complex subunit 2

1

3

High-throughput

0.479

High

1350658

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

8

High-throughput

0.479

High

1353699

ZN384
Zinc finger protein 384

1

1

High-throughput

0.479

High

1361041

P66B
Transcriptional repressor p66-beta

1

1

High-throughput

0.479

High

1365475

ZN592
Zinc finger protein 592

1

1

High-throughput

0.479

High

1365825

ZN516
Zinc finger protein 516

1

1

High-throughput

0.479

High

1396153

Z512B
Zinc finger protein 512B

1

3

High-throughput

0.479

High

1396727

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

3

High-throughput

0.479

High

1396762

EP400
E1A-binding protein p400

1

12

High-throughput

0.479

High

1400274

LENG8
Leukocyte receptor cluster member 8

1

1

High-throughput

0.479

High

1400627

KI20B
Kinesin-like protein KIF20B

1

2

High-throughput

0.479

High

1400797

ATAD5
ATPase family AAA domain-containing protein 5

1

4

High-throughput

0.479

High

1402800

STRBP
Spermatid perinuclear RNA-binding protein

1

5

High-throughput

0.479

High

1403526

MINT
Msx2-interacting protein

1

2

High-throughput

0.479

High

1419523

NSD3
Histone-lysine N-methyltransferase NSD3

1

4

High-throughput

0.479

High

1429923

SP130
Histone deacetylase complex subunit SAP130

1

4

High-throughput

0.479

High

1432795

NELFA
Negative elongation factor A

1

3

High-throughput

0.479

High

1434512

ZN644
Zinc finger protein 644

1

1

High-throughput

0.479

High

1435970

KAT8
Histone acetyltransferase KAT8

1

2

Small-scale

0.479

High

1437844

CLSPN
Claspin

1

1

High-throughput

0.479

High

1439237

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

7

High-throughput

0.479

High

1445913

HM20A
High mobility group protein 20A

1

2

High-throughput

0.479

High

1447225

INCE
Inner centromere protein

1

1

High-throughput

0.479

High

1453451

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

9

High-throughput

0.479

High

1454490

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

8

High-throughput

0.479

High

1459655

TCF20
Transcription factor 20

1

5

High-throughput

0.479

High

1461646

YETS2
YEATS domain-containing protein 2

1

5

High-throughput

0.479

High

1461783

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.479

High

1462039

KMT2B
Histone-lysine N-methyltransferase 2B

1

3

High-throughput

0.479

High

1490620

NCOR2
Nuclear receptor corepressor 2

1

7

High-throughput

0.479

High

141173

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

251673

CCNT1
Cyclin-T1

1

0

High-throughput

0.458

High

335526

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

345221

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.458

High

426600

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

519579

MYBB
Myb-related protein B

1

0

High-throughput

0.458

High

586357

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.458

High

1289791

CASZ1
Zinc finger protein castor homolog 1

1

0

High-throughput

0.458

High

693380

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.458

High

766956

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

770437

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.458

High

775938

HNF1B
Hepatocyte nuclear factor 1-beta

1

0

High-throughput

0.458

High

799595

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

814890

CUX1
Homeobox protein cut-like 1

1

0

High-throughput

0.458

High

883966

CENPF
Centromere protein F

1

0

High-throughput

0.458

High

904418

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

936629

ELL
RNA polymerase II elongation factor ELL

1

0

High-throughput

0.458

High

1029789

FOXK2
Forkhead box protein K2

1

0

High-throughput

0.458

High

1092866

PRDM2
PR domain zinc finger protein 2

1

0

High-throughput

0.458

High

1112806

CUL1
Cullin-1

1

0

Small-scale

0.458

High

1124143

NPAT
Protein NPAT

1

0

High-throughput

0.458

High

1132249

CBX2
Chromobox protein homolog 2

1

0

High-throughput

0.458

High

1132678

MEF2D
Myocyte-specific enhancer factor 2D

1

0

High-throughput

0.458

High

1152397

ZN174
Zinc finger protein 174

1

0

High-throughput

0.458

High

1152763

ELF2
ETS-related transcription factor Elf-2

1

0

High-throughput

0.458

High

1200162

BOREA
Borealin

1

0

High-throughput

0.458

High

1212482

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.458

High

1213162

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.458

High

1229478

CDCA2
Cell division cycle-associated protein 2

1

0

High-throughput

0.458

High

1236085

LIN54
Protein lin-54 homolog

1

0

High-throughput

0.458

High

1244847

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1277262

POGZ
Pogo transposable element with ZNF domain

1

0

High-throughput

0.458

High

1310146

MGAP
MAX gene-associated protein

1

0

High-throughput

0.458

High

1311573

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.458

High

1323193

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.458

High

1323592

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1335896

RN169
E3 ubiquitin-protein ligase RNF169

1

0

High-throughput

0.458

High

1352846

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1365108

PHF3
PHD finger protein 3

1

0

High-throughput

0.458

High

1368017

RREB1
Ras-responsive element-binding protein 1

1

0

High-throughput

0.458

High

1387426

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.458

High

1395317

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.458

High

1398961

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.458

High

1412929

SEN34
tRNA-splicing endonuclease subunit Sen34

1

0

High-throughput

0.458

High

1416510

FANCJ
Fanconi anemia group J protein

1

0

High-throughput

0.458

High

1429825

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

1434739

STEEP
STING ER exit protein

1

0

High-throughput

0.458

High

1447463

ANLN
Anillin

1

0

High-throughput

0.458

High

1451999

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.458

High

1459358

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1459934

TRPS1
Zinc finger transcription factor Trps1

1

0

High-throughput

0.458

High

1461153

C8AP2
CASP8-associated protein 2

1

0

High-throughput

0.458

High

1490616

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.458

High

1490618

ZN281
Zinc finger protein 281

1

0

High-throughput

0.458

High

1490619

SALL2
Sal-like protein 2

1

0

High-throughput

0.458

High

344375

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.445

High

1437415

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.445

High

675206

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.437

High

1178159

QSER1
Glutamine and serine-rich protein 1

1

4

High-throughput

0.437

High

1227733

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

1460912

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

1

High-throughput

0.417

High

116306

H3BPZ6
Codanin 1

1

3

High-throughput

0.407

High

1009370

PRR3
Proline-rich protein 3

3

0

High-throughput

0.352

High

1307680

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

174819

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

0

High-throughput

0.279

Low

649756

SPR1B
Cornifin-B

1

0

High-throughput

0.279

Low

867532

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

921836

COPB
Coatomer subunit beta

1

0

High-throughput

0.279

Low

1052127

CALD1
Caldesmon

1

0

High-throughput

0.279

Low

1124760

SRC8
Src substrate cortactin

1

0

High-throughput

0.279

Low

1294030

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.279

Low

1329366

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

0

High-throughput

0.279

Low

1439509

S10AE
Protein S100-A14

1

0

High-throughput

0.279

Low

1453602

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.279

Low

1414543

HTAI2
Protein HTATIP2

1

0

Small-scale

0.261

Low

1130682

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

1154224

TBCE
Tubulin-specific chaperone E

1

0

High-throughput

0.249

Low

1237852

RADX
RPA-related protein RADX

1

0

High-throughput

0.249

Low

1256152

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1392268

DDX27
Probable ATP-dependent RNA helicase DDX27

1

0

High-throughput

0.249

Low

998166

PA1B2
Platelet-activating factor acetylhydrolase IB subunit alpha2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025