HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: DEN2B (P78524)
DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)
Gene: DENND2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1137
+	Hs
		909436 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN2B_HUMAN (1-1137): 0: 680: 100.00
+	Hs
		646791 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN2B_HUMAN (1-1137): 0: 680: 100.00
+	Hs
		646993 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN2C_HUMAN (149-1136): 0: 568: 43.13
+	Hs
		927224 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYCPP_HUMAN (590-1129): 2.1e-112: 388: 18.77
+	Hs
		909741 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MYCPP_HUMAN (590-1129): 2.1e-112: 388: 18.77
+	Hs
		927176 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DEN1B_HUMAN (692-1120): 2.86e-116: 380: 25.34
+	Hs
		909687 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN1B_HUMAN (692-1120): 2.86e-116: 380: 25.34
+	Hs
		647009 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN1B_HUMAN (692-1120): 2.86e-116: 380: 25.34
+	Hs
		927152 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DEN4C_HUMAN (573-1106): 3.05e-101: 355: 18.80
+	Hs
		909665 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN4C_HUMAN (573-1106): 3.05e-101: 355: 18.80
+	Hs
		646988 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		DEN4C_HUMAN (573-1106): 3.05e-101: 355: 18.80
+	Mm
		926821 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MTMR5_MOUSE (693-1130): 7.7e-96: 339: 17.21
+	Hs
		309464 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MTMR5_HUMAN (693-1130): 2.42e-92: 328: 16.97
+	Hs
		309444 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		MTMR5_HUMAN (693-1130): 2.42e-92: 328: 16.97
+	Hs
		927335 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DEN1A_HUMAN (702-1122): 1.19e-71: 261: 26.07
+	Hs
		909848 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		DEN1A_HUMAN (702-1122): 1.19e-71: 261: 26.07
+	Hs
		926961 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ZO1_HUMAN (2-688): 2.07e-68: 254: 14.05
+	Hs
		927349 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MADD_HUMAN (778-1118): 2.02e-67: 251: 16.82
+	Mm
		926828 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MADD_MOUSE (778-1118): 2.62e-65: 244: 16.82
+	Hs
		646827 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		ZO1_HUMAN (2-688): 2.07e-68: 254: 14.05