Protein: KPCD
Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]

Gene: KPCD, PRKCD
Organism: Homo sapiens
Interactions: 158
UniProt ID: Q05655

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0004699 - diacylglycerol-dependent, calcium-independent serine/threonine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

984482

KPCD
Protein kinase C delta type

8

18

Small-scale

0.965

High

786323

STAT1
Signal transducer and activator of transcription 1-alpha/beta

5

7

Small-scale

0.948

High

666081

SHC1
SHC-transforming protein 1

5

14

Small-scale

0.933

High

984499

ELAV1
ELAV-like protein 1

4

5

Small-scale

0.910

High

435062

SP1
Transcription factor Sp1

3

3

Small-scale

0.845

High

408608

KPCB
Protein kinase C beta type

2

16

High-throughput

0.811

High

981048

KPCT
Protein kinase C theta type

2

18

High-throughput

0.811

High

984514

NGEF
Ephexin-1

2

12

High-throughput

0.811

High

412145

FYN
Tyrosine-protein kinase Fyn

2

17

Small-scale

0.806

High

984491

SQSTM
Sequestosome-1

2

13

Small-scale

0.806

High

724534

IRS1
Insulin receptor substrate 1

2

6

Small-scale

0.768

High

227243

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

411362

INSR
Insulin receptor

2

15

Small-scale

0.754

High

883492

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

2

9

Small-scale

0.754

High

984533

Q9H4D1
Protein kinase

2

7

Small-scale

0.754

High

158454

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.747

High

665871

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

6

Small-scale

0.747

High

167528

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.724

High

587805

NCF2
Neutrophil cytosol factor 2

1

13

Small-scale

0.724

High

776658

STAT3
Signal transducer and activator of transcription 3

1

7

Small-scale

0.724

High

804216

NOTC1
Neurogenic locus notch homolog protein 1

1

3

Small-scale

0.724

High

984512

GRP3
Ras guanyl-releasing protein 3

1

8

Small-scale

0.724

High

182142

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

19

Small-scale

0.713

High

537733

INSRR
Insulin receptor-related protein

1

16

High-throughput

0.691

High

566367

KPCA
Protein kinase C alpha type

1

16

High-throughput

0.691

High

984493

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

19

High-throughput

0.691

High

984495

IL27B
Interleukin-27 subunit beta

1

6

High-throughput

0.691

High

984503

ACTBL
Beta-actin-like protein 2

1

8

High-throughput

0.691

High

984515

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.691

High

621549

IL32
Interleukin-32

4

3

Small-scale

0.691

High

584382

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

7

Small-scale

0.653

High

431767

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.647

High

683287

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.647

High

835339

GSK3A
Glycogen synthase kinase-3 alpha

1

18

Small-scale

0.647

High

984488

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

19

Small-scale

0.647

High

984513

AFAP1
Actin filament-associated protein 1

1

5

Small-scale

0.647

High

984550

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

4

Small-scale

0.647

High

175859

P73
Tumor protein p73

2

4

Small-scale

0.634

High

386583

P53
Cellular tumor antigen p53

2

4

Small-scale

0.634

High

771930

VHL
von Hippel-Lindau disease tumor suppressor

2

7

Small-scale

0.624

High

204167

KLF4
Krueppel-like factor 4

1

5

Small-scale

0.618

High

337439

ABL1
Tyrosine-protein kinase ABL1

1

17

Small-scale

0.618

High

436269

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

522929

SRC
Proto-oncogene tyrosine-protein kinase Src

1

18

Small-scale

0.618

High

681803

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.618

High

770198

IL6RB
Interleukin-6 receptor subunit beta

1

1

Small-scale

0.618

High

848351

IRAK1
Interleukin-1 receptor-associated kinase 1

1

5

Small-scale

0.618

High

900406

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

904475

1433G
14-3-3 protein gamma

1

20

Small-scale

0.618

High

915625

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

926957

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.618

High

984496

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

984505

PPRC1
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

1

9

High-throughput

0.618

High

984507

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

984521

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

1

Small-scale

0.618

High

984534

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

984537

TLR9
Toll-like receptor 9

1

6

Small-scale

0.618

High

984545

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

4

Small-scale

0.618

High

984546

IBTK
Inhibitor of Bruton tyrosine kinase

1

7

Small-scale

0.618

High

984547

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

3

Small-scale

0.618

High

508957

TOP2A
DNA topoisomerase 2-alpha

1

6

Small-scale

0.612

High

394584

A4
Amyloid-beta precursor protein

2

6

High-throughput

0.611

High

843622

FXR1
RNA-binding protein FXR1

2

5

High-throughput

0.611

High

537632

NCF1
Neutrophil cytosol factor 1

2

13

Small-scale

0.602

High

559077

H15
Histone H1.5

2

19

Small-scale

0.602

High

971149

H11
Histone H1.1

2

19

Small-scale

0.602

High

787461

MTOR
Serine/threonine-protein kinase mTOR

2

8

Small-scale

0.601

High

984483

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

4

Small-scale

0.589

High

311690

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

2

2

Small-scale

0.584

High

554297

MUC1
Mucin-1

1

1

Small-scale

0.578

High

91553

E7EVG6
PPARG related coactivator 1

1

7

High-throughput

0.575

High

984501

FSCN1
Fascin

2

3

Small-scale

0.571

High

159359

PLD2
Phospholipase D2

1

2

Small-scale

0.561

High

208129

SPY2
Protein sprouty homolog 2

1

1

Small-scale

0.561

High

965401

FLI1
Friend leukemia integration 1 transcription factor

1

1

Small-scale

0.561

High

570255

NEUM
Neuromodulin

1

0

Small-scale

0.554

High

984530

CAR11
Caspase recruitment domain-containing protein 11

1

12

Small-scale

0.549

High

61208

TPC13
Trafficking protein particle complex subunit 13

1

1

High-throughput

0.536

High

224781

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

2

High-throughput

0.536

High

666890

TKT
Transketolase

1

5

High-throughput

0.536

High

855902

ZN131
Zinc finger protein 131

1

2

High-throughput

0.536

High

900135

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.536

High

984502

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

1

High-throughput

0.536

High

984518

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.536

High

984525

OPALI
Opalin

1

1

High-throughput

0.536

High

984526

DUX3
Putative double homeobox protein 3

1

5

High-throughput

0.536

High

984529

BUD13
BUD13 homolog

1

3

High-throughput

0.536

High

984541

BEX4
Protein BEX4

1

1

High-throughput

0.536

High

984554

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

984485

TROP
Trophinin

1

4

Small-scale

0.515

High

984549

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

6

Small-scale

0.515

High

984553

TRAF6
TNF receptor-associated factor 6

1

15

Small-scale

0.515

High

984531

PIP30
PSME3-interacting protein

1

0

High-throughput

0.513

High

984540

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

984544

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.513

High

984535

CDCP1
CUB domain-containing protein 1

1

0

Small-scale

0.512

High

362080

MBP
Myelin basic protein

1

6

Small-scale

0.501

High

396626

ITB2
Integrin beta-2

1

13

Small-scale

0.501

High

714196

HSP74
Heat shock 70 kDa protein 4

1

15

Small-scale

0.501

High

874857

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.501

High

930813

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

13

Small-scale

0.501

High

957168

DAB2
Disabled homolog 2

1

16

Small-scale

0.501

High

974723

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

6

Small-scale

0.501

High

984484

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.501

High

984486

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.501

High

984494

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.501

High

984497

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

Small-scale

0.501

High

984498

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

3

Small-scale

0.501

High

984504

HABP4
Intracellular hyaluronan-binding protein 4

1

5

Small-scale

0.501

High

984551

HDAC5
Histone deacetylase 5

1

6

Small-scale

0.501

High

984552

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

2

Small-scale

0.501

High

984536

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

Small-scale

0.493

High

984539

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.493

High

984548

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.493

High

984492

NAR3
Ecto-ADP-ribosyltransferase 3

1

0

Small-scale

0.480

High

984510

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

Small-scale

0.480

High

984538

PLS3
Phospholipid scramblase 3

1

0

Small-scale

0.480

High

163794

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

6

High-throughput

0.479

High

322510

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

346596

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

388396

HSPB1
Heat shock protein beta-1

1

14

Small-scale

0.479

High

390842

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

506982

LAMP1
Lysosome-associated membrane glycoprotein 1

1

6

High-throughput

0.479

High

527414

LAMP2
Lysosome-associated membrane glycoprotein 2

1

6

High-throughput

0.479

High

541246

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

3

Small-scale

0.479

High

552553

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

572559

SPI1
Transcription factor PU.1

1

2

Small-scale

0.479

High

632253

TNR6
Tumor necrosis factor receptor superfamily member 6

1

7

High-throughput

0.479

High

718780

PHB1
Prohibitin 1

1

4

Small-scale

0.479

High

742241

SYUA
Alpha-synuclein

1

6

Small-scale

0.479

High

787368

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

7

Small-scale

0.479

High

817958

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

890114

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

984487

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

984489

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

1

Small-scale

0.479

High

984490

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

984500

CCDC6
Coiled-coil domain-containing protein 6

1

8

High-throughput

0.479

High

984506

RBP10
Ran-binding protein 10

1

5

Small-scale

0.479

High

984508

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

984509

GOLI
E3 ubiquitin-protein ligase RNF130

1

5

High-throughput

0.479

High

984517

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.479

High

984519

TRI41
E3 ubiquitin-protein ligase TRIM41

1

7

Small-scale

0.479

High

984520

AKAP1
A-kinase anchor protein 1, mitochondrial

1

4

High-throughput

0.479

High

984527

RANB9
Ran-binding protein 9

1

5

Small-scale

0.479

High

984532

P63
Tumor protein 63

1

4

Small-scale

0.479

High

984543

MTCH1
Mitochondrial carrier homolog 1

1

15

High-throughput

0.479

High

984516

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

984522

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

984523

T53I1
Tumor protein p53-inducible nuclear protein 1

1

0

Small-scale

0.458

High

984528

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

241512

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.445

High

973316

TOP2B
DNA topoisomerase 2-beta

1

6

Small-scale

0.445

High

984542

BCLF1
Bcl-2-associated transcription factor 1

1

3

Small-scale

0.445

High

86687

C6GKH1
Interleukin 32

1

3

Small-scale

0.437

High

708871

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.426

High

984511

LYSM2
LysM and putative peptidoglycan-binding domain-containing protein 2

1

0

High-throughput

0.279

Low

984524

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024