Interactor 1: ATX3 (P54252)
Ataxin-3 (EC 3.4.19.12) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein)
Gene: ATXN3
Interactor 2: BECN1 (Q14457)
Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]
Gene: BECN1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.61 | 0.60 | 0.610 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28445460 |
| Identification Methods | affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation, deubiquitinase assay, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, deubiquitination reaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0034198 - cellular response to amino acid starvation |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
