Protein: JOS1
Josephin-1 (EC 3.4.19.12) (Josephin domain-containing protein 1)

Gene: JOS1, JOSD1
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q15040

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006508 - proteolysis
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508002

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

5

Small-scale

0.899

High

950482

KR108
Keratin-associated protein 10-8

3

8

High-throughput

0.675

High

1139173

K1C40
Keratin, type I cytoskeletal 40

3

3

High-throughput

0.675

High

1139186

KRA92
Keratin-associated protein 9-2

3

9

High-throughput

0.675

High

131432

EIF3F
Eukaryotic translation initiation factor 3 subunit F

3

2

High-throughput

0.667

High

1139171

K1H1
Keratin, type I cuticular Ha1

2

3

High-throughput

0.633

High

571981

TRI27
Zinc finger protein RFP

2

0

High-throughput

0.613

High

300357

KRT34
Keratin, type I cuticular Ha4

2

3

High-throughput

0.606

High

1059636

KRA11
Keratin-associated protein 1-1

2

8

High-throughput

0.606

High

1139176

K1C27
Keratin, type I cytoskeletal 27

2

2

High-throughput

0.606

High

1139177

KRA13
Keratin-associated protein 1-3

2

8

High-throughput

0.606

High

1139185

KRA93
Keratin-associated protein 9-3

2

9

High-throughput

0.606

High

1060262

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

1

Small-scale

0.584

High

227224

KRT86
Keratin, type II cuticular Hb6

2

0

High-throughput

0.580

High

652317

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

0

High-throughput

0.580

High

949539

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.580

High

1139175

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.578

High

685850

KRA59
Keratin-associated protein 5-9

1

8

High-throughput

0.573

High

1093819

TRAF1
TNF receptor-associated factor 1

1

2

High-throughput

0.573

High

1022253

FBLN2
Fibulin-2

2

1

High-throughput

0.553

High

1139172

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

3

High-throughput

0.553

High

1139174

ATL4
ADAMTS-like protein 4

2

1

High-throughput

0.553

High

783275

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.549

High

518600

RAP2A
Ras-related protein Rap-2a

1

1

High-throughput

0.536

High

1139189

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

11

High-throughput

0.523

High

950217

KR104
Keratin-associated protein 10-4

1

6

High-throughput

0.515

High

1139187

KRA24
Keratin-associated protein 2-4

1

9

High-throughput

0.515

High

1139182

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

3

High-throughput

0.501

High

1139190

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

2

High-throughput

0.501

High

1139191

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.501

High

1139192

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

High-throughput

0.501

High

505320

KRA23
Keratin-associated protein 2-3

1

9

High-throughput

0.481

High

949878

KR103
Keratin-associated protein 10-3

1

9

High-throughput

0.481

High

170146

AURKA
Aurora kinase A

1

3

Small-scale

0.479

High

193275

SOCS1
Suppressor of cytokine signaling 1

1

1

Small-scale

0.479

High

253352

JAK2
Tyrosine-protein kinase JAK2

1

1

Small-scale

0.479

High

350007

SNAI1
Zinc finger protein SNAI1

1

1

Small-scale

0.479

High

764762

CTNB1
Catenin beta-1

1

2

Small-scale

0.479

High

1107733

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

1126684

BECN1
Beclin-1

1

1

Small-scale

0.479

High

1139178

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

2

Small-scale

0.479

High

517006

NT2NC
Notch homolog 2 N-terminal-like protein C

1

1

High-throughput

0.470

High

279166

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.458

High

1139179

PJA1
E3 ubiquitin-protein ligase Praja-1

1

4

High-throughput

0.457

High

1139181

TRI63
E3 ubiquitin-protein ligase TRIM63

1

10

High-throughput

0.457

High

1139188

TRI54
Tripartite motif-containing protein 54

1

10

High-throughput

0.457

High

521

NBPFJ
NBPF family member NBPF19

1

1

High-throughput

0.439

High

70214

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1139183

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

1139184

CAR10
Caspase recruitment domain-containing protein 10

2

0

High-throughput

0.316

High

238710

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

0

High-throughput

0.279

Low

692699

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.279

Low

1139180

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025