HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: PK3C3 (Q8NEB9)
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)
Gene: PIK3C3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36042481
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042149 - cellular response to glucose starvation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 887
+	Hs
		647121 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		PK3C3_HUMAN (1-887): 0: 999: 100.00
+	Hs
		646704 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		PK3CB_HUMAN (43-886): 0: 586: 21.06
+	Mm
		787345 1433G_MOUSE (1-240): 2.37e-108: 314: 74.59		PK3CA_MOUSE (46-884): 0: 582: 20.30
+	Hs
		128838 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		P3C2A_HUMAN (112-883): 6.36e-147: 476: 20.64
+	Hs
		128836 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		P3C2A_HUMAN (112-883): 6.36e-147: 476: 20.64
+	Hs
		128810 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		P3C2A_HUMAN (112-883): 6.36e-147: 476: 20.64
+	Hs
		128813 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		P3C2A_HUMAN (112-883): 6.36e-147: 476: 20.64
+	Dm
		664613 1433Z_DROME (1-245): 3.35e-143: 402: 81.22		Q7K3H0_DROME (195-883): 3.52e-127: 423: 19.50
+	At
		788647 14333_ARATH (3-239): 1.48e-141: 398: 64.73		ATM_ARATH (175-884): 9.74e-126: 421: 15.47
+	Hs
		128834 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		P3C2A_HUMAN (112-883): 6.36e-147: 476: 20.64
+	Hs
		904645 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		Q4LE69_HUMAN (397-886): 5.43e-116: 392: 20.90
+	Hs
		927618 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PI4KB_HUMAN (605-884): 2.87e-86: 295: 25.34
+	Hs
		910120 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		PI4KB_HUMAN (605-884): 2.87e-86: 295: 25.34
+	Hs
		647352 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		PI4KB_HUMAN (605-884): 2.87e-86: 295: 25.34
+	Hs
		683785 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		PI4KB_HUMAN (605-884): 2.87e-86: 295: 25.34
+	Hs
		135776 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		P3C2B_HUMAN (31-478): 1.7e-26: 119: 14.66
+	Hs
		135774 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		P3C2B_HUMAN (31-478): 1.7e-26: 119: 14.66
+	Hs
		135766 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		P3C2B_HUMAN (31-478): 1.7e-26: 119: 14.66
+	Hs
		135769 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		P3C2B_HUMAN (31-478): 1.7e-26: 119: 14.66
+	Hs
		135773 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		P3C2B_HUMAN (31-478): 1.7e-26: 119: 14.66