HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	12176984, 35271311
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1164
+	Mm
		926881 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Mm
		910338 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		927035 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		926974 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CGNL1_HUMAN (280-1054): 5.93e-34: 144: 11.22
+	Hs
		728466 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64
+	Hs
		728460 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MYH11_HUMAN (392-1122): 2.73e-28: 126: 8.64
+	Hs
		724761 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		551660 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		927643 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYH2_HUMAN (393-980): 6.89e-21: 101: 11.32
+	Mm
		926855 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MYH9_MOUSE (753-1164): 6.75e-17: 88.7: 9.71
+	Hs
		522602 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYH7_HUMAN (391-922): 3.39e-17: 89.9: 8.59
+	Hs
		927145 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Mm
		926886 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MY18A_MOUSE (693-1156): 2.57e-14: 80.2: 9.53
+	Hs
		927241 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PHLB1_HUMAN (280-850): 6.61e-14: 79.1: 11.33
+	Mm
		926804 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		MYH10_MOUSE (760-1162): 4.89e-13: 76: 9.30
+	Mm
		93548 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		DESP_MOUSE (718-1164): 2.9e-13: 77.2: 10.89
+	Hs
		927123 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41
+	Hs
		502907 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYH3_HUMAN (400-850): 1.77e-10: 67.9: 10.00
+	Hs
		927644 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MYH13_HUMAN (628-994): 2.22e-10: 67.5: 20.45
+	Hs
		725130 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43