HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: AKTS1 (Q96B36)
Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
Gene: AKT1S1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	17277771, 35271311, 15161933
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 256
+	Hs
		909890 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AKTS1_HUMAN (1-256): 4.07e-135: 382: 100.00
+	Hs
		647174 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		AKTS1_HUMAN (1-256): 4.07e-135: 382: 100.00
+	Hs
		683608 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		AKTS1_HUMAN (1-256): 4.07e-135: 382: 100.00
+	Mm
		933141 1433T_MOUSE (1-245): 8.98e-140: 393: 79.18		AKTS1_MOUSE (1-256): 1.59e-121: 348: 92.61
+	Hs
		904962 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		AKTS1_HUMAN (1-256): 4.07e-135: 382: 100.00
+	Hs
		982365 1433F_HUMAN (2-240): 1.26e-107: 312: 74.49		AKTS1_HUMAN (1-256): 4.07e-135: 382: 100.00