Protein: UBP46
Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)

Gene: UBP46, USP46
Organism: Homo sapiens
Interactions: 96
UniProt ID: P62068

Gene Ontology (top 5):
GO:0001662 - behavioral fear response
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

967159

WDR48
WD repeat-containing protein 48

13

11

Small-scale

0.981

High

967160

WDR20
WD repeat-containing protein 20

12

16

Small-scale

0.978

High

967144

DMWD
Dystrophia myotonica WD repeat-containing protein

7

17

Small-scale

0.962

High

275882

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

4

12

Small-scale

0.881

High

247278

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

9

5

Small-scale

0.756

High

967155

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

6

5

High-throughput

0.735

High

967166

R51A1
RAD51-associated protein 1

4

1

High-throughput

0.699

High

255408

SNX2
Sorting nexin-2

4

2

High-throughput

0.691

High

967186

SNX6
Sorting nexin-6

3

2

High-throughput

0.667

High

967158

TSYL6
Testis-specific Y-encoded-like protein 6

3

5

High-throughput

0.662

High

507772

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

967139

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

7

Small-scale

0.647

High

561117

GILT
Gamma-interferon-inducible lysosomal thiol reductase

3

0

High-throughput

0.638

High

967154

RN19B
E3 ubiquitin-protein ligase RNF19B

2

8

High-throughput

0.628

High

967173

GORS1
Golgi reassembly-stacking protein 1

2

1

High-throughput

0.628

High

967175

THUM3
tRNA

2

1

High-throughput

0.628

High

317158

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

15

High-throughput

0.618

High

967172

MEP50
Methylosome protein WDR77

1

9

Small-scale

0.618

High

967176

WDR26
WD repeat-containing protein 26

1

10

Small-scale

0.618

High

536891

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.611

High

952709

ACTB
Actin, cytoplasmic 1

2

0

High-throughput

0.585

High

507144

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.575

High

967185

UBQL1
Ubiquilin-1

1

4

High-throughput

0.575

High

630147

ACM3
Muscarinic acetylcholine receptor M3

2

2

High-throughput

0.574

High

967146

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

0

High-throughput

0.551

High

208494

PJA2
E3 ubiquitin-protein ligase Praja-2

1

6

High-throughput

0.536

High

729723

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

862781

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

High-throughput

0.536

High

966166

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

967138

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.536

High

967140

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

967141

SET
Protein SET

1

5

High-throughput

0.536

High

967143

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

967152

SGO1
Shugoshin 1

1

1

High-throughput

0.536

High

967169

NEB2
Neurabin-2

1

2

High-throughput

0.536

High

967183

E2AK4
eIF-2-alpha kinase GCN2

1

1

High-throughput

0.536

High

967189

USH1C
Harmonin

1

3

High-throughput

0.536

High

967164

H2B1H
Histone H2B type 1-H

1

16

High-throughput

0.515

High

927215

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

880089

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.513

High

967153

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

838446

GRIA1
Glutamate receptor 1

1

1

Small-scale

0.501

High

967150

H2A2C
Histone H2A type 2-C

1

14

Small-scale

0.501

High

967151

H2B2E
Histone H2B type 2-E

1

16

Small-scale

0.501

High

967180

VSX1
Visual system homeobox 1

1

3

High-throughput

0.500

High

967161

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

1

High-throughput

0.489

High

967168

OPALI
Opalin

1

1

High-throughput

0.489

High

967178

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

4

High-throughput

0.489

High

172650

XPO1
Exportin-1

1

2

High-throughput

0.479

High

616164

PGAM1
Phosphoglycerate mutase 1

1

1

Small-scale

0.479

High

952534

MYL6
Myosin light polypeptide 6

1

1

High-throughput

0.479

High

967145

STK4
Serine/threonine-protein kinase 4

1

6

Small-scale

0.479

High

967149

CIRBP
Cold-inducible RNA-binding protein

1

4

High-throughput

0.479

High

967187

SHOC2
Leucine-rich repeat protein SHOC-2

1

2

Small-scale

0.479

High

270914

CLAP2
CLIP-associating protein 2

1

2

High-throughput

0.445

High

343574

OXSR1
Serine/threonine-protein kinase OSR1

1

7

High-throughput

0.445

High

360181

GSHR
Glutathione reductase, mitochondrial

1

1

High-throughput

0.445

High

573941

MYL6B
Myosin light chain 6B

1

1

High-throughput

0.445

High

657362

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.445

High

767085

SPB6
Serpin B6

1

1

High-throughput

0.445

High

854810

RECQ1
ATP-dependent DNA helicase Q1

1

5

High-throughput

0.445

High

892450

GUAA
GMP synthase [glutamine-hydrolyzing]

1

1

High-throughput

0.445

High

901168

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.445

High

967142

TAGL
Transgelin

1

2

High-throughput

0.445

High

967148

SNX1
Sorting nexin-1

1

2

High-throughput

0.445

High

967167

OTUB1
Ubiquitin thioesterase OTUB1

1

3

High-throughput

0.445

High

967188

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

1

High-throughput

0.445

High

710158

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.437

High

967157

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.437

High

48350

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

0

High-throughput

0.426

High

135573

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.426

High

176659

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.426

High

192234

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.426

High

211483

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

0

High-throughput

0.426

High

217258

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.426

High

300134

GLRX3
Glutaredoxin-3

1

0

High-throughput

0.426

High

570873

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.426

High

611072

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.426

High

663354

KTHY
Thymidylate kinase

1

0

High-throughput

0.426

High

786323

PGM1
Phosphoglucomutase-1

1

0

High-throughput

0.426

High

888693

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

0

High-throughput

0.426

High

967147

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.426

High

967163

NDRG1
Protein NDRG1

1

0

High-throughput

0.426

High

967165

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.426

High

967179

ADPRS
ADP-ribosylhydrolase ARH3

1

0

High-throughput

0.426

High

967181

LMCD1
LIM and cysteine-rich domains protein 1

1

0

High-throughput

0.426

High

967162

RAB2B
Ras-related protein Rab-2B

1

1

High-throughput

0.407

High

967170

CNN2
Calponin-2

1

2

High-throughput

0.407

High

967182

Q9P1S2
HDCMD34P

1

3

High-throughput

0.407

High

476433

IBP1
Insulin-like growth factor-binding protein 1

1

0

High-throughput

0.279

Low

967174

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.279

Low

845417

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

0

High-throughput

0.249

Low

967156

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low

967171

SNAG
Gamma-soluble NSF attachment protein

1

0

High-throughput

0.232

Low

967177

HEBP1
Heme-binding protein 1

1

0

High-throughput

0.232

Low

967184

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025