HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: WNK1 (Q9H4A3)
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)
Gene: WNK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	35271311, 36931259, 20936779
Identification Methods	affinity chromatography technology, proximity labelling technology, two hybrid, two hybrid pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0007165 - signal transduction and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 2382
+	Hs
		927697 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		WNK2_HUMAN (128-2196): 8.79e-129: 455: 26.11
+	Hs
		927425 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		NEK1_HUMAN (218-1352): 1.24e-125: 432: 13.77
+	Mm
		659446 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		KCC2B_MOUSE (219-657): 2.88e-126: 411: 19.73
+	Mm
		926866 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		KCC2G_MOUSE (219-657): 6.82e-126: 409: 20.18
+	Mm
		926819 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		KCC2D_MOUSE (219-633): 6.74e-126: 408: 19.91
+	Hs
		909532 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KCC2D_HUMAN (219-633): 6.74e-126: 408: 19.91
+	Mm
		515221 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		KCC2A_MOUSE (219-633): 4.07e-124: 402: 18.96
+	Hs
		926993 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AAPK1_HUMAN (195-737): 1.29e-123: 404: 16.40
+	Hs
		681776 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Rn
		871214 1433E_RAT (2-241): 9.9e-144: 403: 68.18		AAPK1_RAT (195-737): 1.4e-123: 404: 16.58
+	Hs
		909507 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AAPK1_HUMAN (195-737): 1.29e-123: 404: 16.40
+	Hs
		681770 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Hs
		927014 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		KCC2G_HUMAN (221-657): 2.57e-116: 383: 19.24
+	Hs
		909531 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KCC2G_HUMAN (221-657): 2.57e-116: 383: 19.24
+	Hs
		851437 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		NEK4_HUMAN (227-488): 1.08e-24: 115: 30.71
+	Hs
		851417 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		NEK4_HUMAN (227-488): 1.08e-24: 115: 30.71
+	Hs
		927406 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		WNK4_HUMAN (1724-2142): 2.06e-16: 88.5: 22.20
+	Hs
		909911 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		WNK4_HUMAN (1724-2142): 2.06e-16: 88.5: 22.20
+	Hs
		927301 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MINK1_HUMAN (604-1227): 3.59e-09: 64.8: 11.68
+	Hs
		909810 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MINK1_HUMAN (604-1227): 3.59e-09: 64.8: 11.68