Protein: LHX2
LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)

Gene: LHX2
Organism: Homo sapiens
Interactions: 178
UniProt ID: P50458

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

895744

LDB1
LIM domain-binding protein 1

4

20

High-throughput

0.904

High

725030

HXC8
Homeobox protein Hox-C8

2

15

High-throughput

0.783

High

895709

PO4F2
POU domain, class 4, transcription factor 2

2

20

High-throughput

0.783

High

895804

HOME3
Homer protein homolog 3

2

5

High-throughput

0.700

High

895792

SSBP3
Single-stranded DNA-binding protein 3

3

20

High-throughput

0.667

High

685131

PAX6
Paired box protein Pax-6

1

9

Small-scale

0.647

High

703263

MSX1
Homeobox protein MSX-1

1

20

Small-scale

0.647

High

814769

CUX1
Homeobox protein cut-like 1

1

17

High-throughput

0.618

High

895704

SATB1
DNA-binding protein SATB1

1

7

High-throughput

0.618

High

895716

MEF2D
Myocyte-specific enhancer factor 2D

1

3

High-throughput

0.618

High

895721

ZFHX3
Zinc finger homeobox protein 3

1

11

High-throughput

0.618

High

895731

BCORL
BCL-6 corepressor-like protein 1

1

4

High-throughput

0.618

High

895740

BCOR
BCL-6 corepressor

1

18

High-throughput

0.618

High

895746

ZFHX4
Zinc finger homeobox protein 4

1

14

High-throughput

0.618

High

895750

MGAP
MAX gene-associated protein

1

11

High-throughput

0.618

High

895773

ISL2
Insulin gene enhancer protein ISL-2

1

17

High-throughput

0.618

High

895779

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

17

High-throughput

0.618

High

895800

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

12

High-throughput

0.618

High

895812

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.618

High

895819

SATB2
DNA-binding protein SATB2

1

7

High-throughput

0.618

High

895829

ZHX2
Zinc fingers and homeoboxes protein 2

1

19

High-throughput

0.618

High

895791

SSBP4
Single-stranded DNA-binding protein 4

2

20

High-throughput

0.611

High

506155

UBFL1
Upstream-binding factor 1-like protein 1

2

17

High-throughput

0.606

High

895754

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

2

High-throughput

0.606

High

895756

ZN511
Zinc finger protein 511

2

2

High-throughput

0.606

High

895782

ZFP42
Zinc finger protein 42 homolog

2

15

High-throughput

0.606

High

895816

TLK1
Serine/threonine-protein kinase tousled-like 1

2

3

High-throughput

0.606

High

895817

TPC2L
Trafficking protein particle complex subunit 2-like protein

2

1

High-throughput

0.606

High

895825

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

2

1

High-throughput

0.606

High

895739

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.580

High

895757

BEND2
BEN domain-containing protein 2

2

0

High-throughput

0.580

High

895811

MO4L1
Mortality factor 4-like protein 1

2

0

High-throughput

0.580

High

142898

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.578

High

895710

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.578

High

895787

CITE2
Cbp/p300-interacting transactivator 2

1

1

Small-scale

0.573

High

473861

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.561

High

895765

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

7

High-throughput

0.555

High

67635

RHG32
Rho GTPase-activating protein 32

2

4

High-throughput

0.553

High

893010

KHK
Ketohexokinase

2

1

High-throughput

0.553

High

895723

LONF1
LON peptidase N-terminal domain and RING finger protein 1

2

5

High-throughput

0.553

High

895762

LNX1
E3 ubiquitin-protein ligase LNX

2

2

High-throughput

0.553

High

895784

OSMR
Oncostatin-M-specific receptor subunit beta

2

5

High-throughput

0.553

High

895827

PYGO1
Pygopus homolog 1

1

20

High-throughput

0.489

High

895814

DNM3L
DNA

1

0

Small-scale

0.480

High

895706

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.479

High

154652

ARI1A
AT-rich interactive domain-containing protein 1A

1

20

High-throughput

0.479

High

161436

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

174328

ZN609
Zinc finger protein 609

1

12

High-throughput

0.479

High

177447

ZN536
Zinc finger protein 536

1

6

High-throughput

0.479

High

180751

TIF1A
Transcription intermediary factor 1-alpha

1

12

High-throughput

0.479

High

186630

HMGB3
High mobility group protein B3

1

14

High-throughput

0.479

High

194530

KDM6A
Lysine-specific demethylase 6A

1

7

High-throughput

0.479

High

238444

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

245602

ZEB2
Zinc finger E-box-binding homeobox 2

1

7

High-throughput

0.479

High

272805

PHF2
Lysine-specific demethylase PHF2

1

5

High-throughput

0.479

High

278277

NCOR1
Nuclear receptor corepressor 1

1

18

High-throughput

0.479

High

282688

E2F6
Transcription factor E2F6

1

3

High-throughput

0.479

High

344898

WIZ
Protein Wiz

1

9

High-throughput

0.479

High

481163

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

541894

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.479

High

559741

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

16

High-throughput

0.479

High

586252

ZEP1
Zinc finger protein 40

1

18

High-throughput

0.479

High

675420

TYY1
Transcriptional repressor protein YY1

1

15

High-throughput

0.479

High

703283

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

11

High-throughput

0.479

High

769951

RFC1
Replication factor C subunit 1

1

5

High-throughput

0.479

High

878788

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

19

High-throughput

0.479

High

886372

CTCF
Transcriptional repressor CTCF

1

4

High-throughput

0.479

High

895692

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

11

High-throughput

0.479

High

895693

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

12

High-throughput

0.479

High

895694

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

895695

BLM
RecQ-like DNA helicase BLM

1

2

High-throughput

0.479

High

895696

ATX1
Ataxin-1

1

5

High-throughput

0.479

High

895698

SSBP2
Single-stranded DNA-binding protein 2

1

20

High-throughput

0.479

High

895702

FOXK1
Forkhead box protein K1

1

12

High-throughput

0.479

High

895703

TFAM
Transcription factor A, mitochondrial

1

18

High-throughput

0.479

High

895705

TLE1
Transducin-like enhancer protein 1

1

12

High-throughput

0.479

High

895707

RING1
E3 ubiquitin-protein ligase RING1

1

5

High-throughput

0.479

High

895708

TLE5
TLE family member 5

1

10

High-throughput

0.479

High

895711

PWP1
Periodic tryptophan protein 1 homolog

1

3

High-throughput

0.479

High

895713

SMC1A
Structural maintenance of chromosomes protein 1A

1

4

High-throughput

0.479

High

895714

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

7

High-throughput

0.479

High

895715

RRP5
Protein RRP5 homolog

1

1

High-throughput

0.479

High

895717

RBBP5
Retinoblastoma-binding protein 5

1

1

High-throughput

0.479

High

895718

SSXT
Protein SSXT

1

13

High-throughput

0.479

High

895719

ELF2
ETS-related transcription factor Elf-2

1

6

High-throughput

0.479

High

895720

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

1

High-throughput

0.479

High

895722

TAF12
Transcription initiation factor TFIID subunit 12

1

2

High-throughput

0.479

High

895727

ARI4B
AT-rich interactive domain-containing protein 4B

1

20

High-throughput

0.479

High

895728

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

8

High-throughput

0.479

High

895735

TSH3
Teashirt homolog 3

1

12

High-throughput

0.479

High

895736

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

895741

PAXI1
PAX-interacting protein 1

1

12

High-throughput

0.479

High

895742

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.479

High

895743

POGZ
Pogo transposable element with ZNF domain

1

8

High-throughput

0.479

High

895745

PB1
Protein polybromo-1

1

16

High-throughput

0.479

High

895747

BCL9L
B-cell CLL/lymphoma 9-like protein

1

20

High-throughput

0.479

High

895748

FOXP4
Forkhead box protein P4

1

16

High-throughput

0.479

High

895749

ARI3B
AT-rich interactive domain-containing protein 3B

1

20

High-throughput

0.479

High

895751

HOMEZ
Homeobox and leucine zipper protein Homez

1

19

High-throughput

0.479

High

895758

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

895759

ARI1B
AT-rich interactive domain-containing protein 1B

1

20

High-throughput

0.479

High

895760

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

895761

SMRC2
SWI/SNF complex subunit SMARCC2

1

18

High-throughput

0.479

High

895764

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

895766

RREB1
Ras-responsive element-binding protein 1

1

4

High-throughput

0.479

High

895767

DPF1
Zinc finger protein neuro-d4

1

20

High-throughput

0.479

High

895768

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

895769

SMRC1
SWI/SNF complex subunit SMARCC1

1

18

High-throughput

0.479

High

895770

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

18

High-throughput

0.479

High

895771

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

14

High-throughput

0.479

High

895772

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

High-throughput

0.479

High

895775

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

12

High-throughput

0.479

High

895777

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

7

High-throughput

0.479

High

895778

Z512B
Zinc finger protein 512B

1

12

High-throughput

0.479

High

895780

EP400
E1A-binding protein p400

1

13

High-throughput

0.479

High

895781

ZN512
Zinc finger protein 512

1

9

High-throughput

0.479

High

895783

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

895786

ARI3A
AT-rich interactive domain-containing protein 3A

1

20

High-throughput

0.479

High

895789

BCL7B
B-cell CLL/lymphoma 7 protein family member B

1

8

High-throughput

0.479

High

895793

GTPB4
GTP-binding protein 4

1

4

High-throughput

0.479

High

895794

REXO4
RNA exonuclease 4

1

1

High-throughput

0.479

High

895796

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

1

High-throughput

0.479

High

895797

FOXP1
Forkhead box protein P1

1

16

High-throughput

0.479

High

895798

ZN644
Zinc finger protein 644

1

8

High-throughput

0.479

High

895799

DDX31
ATP-dependent DNA helicase DDX31

1

1

High-throughput

0.479

High

895802

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

895803

HELLS
Lymphoid-specific helicase

1

12

High-throughput

0.479

High

895807

DDX56
Probable ATP-dependent RNA helicase DDX56

1

5

High-throughput

0.479

High

895809

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

6

High-throughput

0.479

High

895810

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.479

High

895813

BAZ1B
Tyrosine-protein kinase BAZ1B

1

17

High-throughput

0.479

High

895820

SMC3
Structural maintenance of chromosomes protein 3

1

4

High-throughput

0.479

High

895828

NCOR2
Nuclear receptor corepressor 2

1

12

High-throughput

0.479

High

895726

Q49AR9
ANKS1A protein

1

2

High-throughput

0.470

High

824051

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.458

High

855000

NOP2
28S rRNA

1

0

High-throughput

0.458

High

895697

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

895712

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.458

High

895725

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.458

High

895733

LIN9
Protein lin-9 homolog

1

0

High-throughput

0.458

High

895738

LIN54
Protein lin-54 homolog

1

0

High-throughput

0.458

High

895763

NOC3L
Nucleolar complex protein 3 homolog

1

0

High-throughput

0.458

High

895801

SHCAF
SIN3-HDAC complex-associated factor

1

0

High-throughput

0.458

High

839530

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.457

High

138982

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.437

High

345534

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.437

High

841303

RBM34
RNA-binding protein 34

1

2

High-throughput

0.437

High

895700

RT15
Small ribosomal subunit protein uS15m

1

1

High-throughput

0.437

High

895730

IF44L
Interferon-induced protein 44-like

1

1

High-throughput

0.437

High

895734

ZMYM4
Zinc finger MYM-type protein 4

1

11

High-throughput

0.437

High

895752

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

2

High-throughput

0.437

High

895753

ZN687
Zinc finger protein 687

1

5

High-throughput

0.437

High

895776

DDX27
Probable ATP-dependent RNA helicase DDX27

1

2

High-throughput

0.437

High

895790

CHOLN
Protein cholesin

1

3

High-throughput

0.437

High

895795

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

895806

RBM28
RNA-binding protein 28

1

4

High-throughput

0.437

High

895818

RL26L
Ribosomal protein uL24-like

1

2

High-throughput

0.437

High

895822

DDX52
Probable ATP-dependent RNA helicase DDX52

1

1

High-throughput

0.437

High

895823

RM11
Large ribosomal subunit protein uL11m

1

2

High-throughput

0.437

High

895824

NOP16
Nucleolar protein 16

1

1

High-throughput

0.437

High

895724

LEGL
Galectin-related protein

2

0

High-throughput

0.316

High

895729

FWCH1
FLYWCH-type zinc finger-containing protein 1

2

0

High-throughput

0.316

High

895805

T11L1
T-complex protein 11-like protein 1

2

0

High-throughput

0.316

High

65722

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

290490

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.249

Low

895691

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.249

Low

895699

RT05
Small ribosomal subunit protein uS5m

1

0

High-throughput

0.249

Low

895701

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.249

Low

895732

RRP12
RRP12-like protein

1

0

High-throughput

0.249

Low

895737

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.249

Low

895755

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.249

Low

895774

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.249

Low

895785

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.249

Low

895788

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.249

Low

895808

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.249

Low

895815

MRT4
mRNA turnover protein 4 homolog

1

0

High-throughput

0.249

Low

895821

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.249

Low

895826

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025