HitPredict

Interactor 1: UBE2B (P63146)
Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)
Gene: UBE2B

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 25582440, 28514442, 33961781, 21443952, 19410543, 27569044, 37633270
Identification Methods affinity chromatography technology, pull down, enzymatic study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~zf-C3HC4
Common GO terms GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
and 2 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 152
Hs

1 975
+ Hs
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+ At
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+ Hs
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+ Sc
+ Sp
+ At
+ At
+ Ce
+ Sp
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024