HitPredict

Interactor 1: HMGB1 (P63158)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: TLE1 (Q62440)
Transducin-like enhancer protein 1 (Groucho-related protein 1) (Grg-1)
Gene: TLE1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	11748221
Identification Methods	pull down, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Mm			1 770
+	Hs
		449690 HMGB1_HUMAN (1-174): 6.46e-41: 140: 100.00		TLE1_HUMAN (1-770): 0: 582: 97.15
+	Hs
		817954 SOX2_HUMAN (3-94): 4.01e-22: 93.6: 23.91		TLE1_HUMAN (1-770): 0: 582: 97.15
+	Hs
		980847 CIC_HUMAN (57-210): 2.81e-30: 119: 19.48		TLE3_HUMAN (1-770): 5.8e-175: 523: 77.55
+	Dm
		558375 DICH_DROME (8-101): 1.81e-24: 100: 24.47		GROU_DROME (1-770): 4.37e-137: 423: 59.04
+	Hs
		449697 HMGB1_HUMAN (1-174): 6.46e-41: 140: 100.00		TLE5_HUMAN (1-200): 2.67e-90: 283: 64.00
+	Mm
		925827 HMGB1_MOUSE (1-174): 6.46e-41: 140: 100.00		TLE5_MOUSE (1-200): 2.25e-90: 283: 64.00
+	Hs
		178916 TOX3_HUMAN (91-165): 2.47e-29: 116: 40.00		TLE5_HUMAN (1-200): 2.67e-90: 283: 64.00
+	Hs
		996881 SSRP1_HUMAN (53-164): 9.71e-28: 111: 37.50		TBL1R_HUMAN (569-769): 6.07e-47: 176: 15.07
+	Hs
		245594 SSRP1_HUMAN (53-164): 9.71e-28: 111: 37.50		TBL1X_HUMAN (569-769): 5.84e-46: 175: 16.06
+	Hs
		449632 HMGB1_HUMAN (1-174): 6.46e-41: 140: 100.00		WDR5_HUMAN (655-769): 9.47e-36: 140: 21.37
+	Hs
		643290 HMGB2_HUMAN (1-187): 3e-39: 135: 82.89		WDR5_HUMAN (655-769): 9.47e-36: 140: 21.37
+	Hs
		245575 SOX2_HUMAN (3-94): 4.01e-22: 93.6: 23.91		TBL1X_HUMAN (569-769): 5.84e-46: 175: 16.06
+	Hs
		903130 TFAM_HUMAN (9-189): 1.33e-32: 119: 20.79		WDR5_HUMAN (655-769): 9.47e-36: 140: 21.37
+	Hs
		903450 CIC_HUMAN (57-210): 2.81e-30: 119: 19.48		WDR5_HUMAN (655-769): 9.47e-36: 140: 21.37
+	Hs
		903169 SSRP1_HUMAN (53-164): 9.71e-28: 111: 37.50		WDR5_HUMAN (655-769): 9.47e-36: 140: 21.37
+	Hs
		817868 SOX2_HUMAN (3-94): 4.01e-22: 93.6: 23.91		WDR5_HUMAN (655-769): 9.47e-36: 140: 21.37
+	Hs
		996930 SSRP1_HUMAN (53-164): 9.71e-28: 111: 37.50		NLE1_HUMAN (385-510): 9.38e-17: 86: 14.96
+	Hs
		197008 SSRP1_HUMAN (53-164): 9.71e-28: 111: 37.50		PRP4_HUMAN (535-761): 1.04e-11: 70.1: 26.92
+	Hs
		996824 SSRP1_HUMAN (53-164): 9.71e-28: 111: 37.50		SNR40_HUMAN (507-675): 1.04e-09: 62.8: 28.18
+	Hs
		196970 SOX2_HUMAN (3-94): 4.01e-22: 93.6: 23.91		PRP4_HUMAN (535-761): 1.04e-11: 70.1: 26.92