HitPredict

Interactor 1: SUMO1 (P63165)
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Gene: SUMO1

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18093978
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 101 Hs			1 522
+	Hs
		1241456 NF2IP_HUMAN (10-90): 2.19e-25: 99.4: 26.83		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		928083 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		102158 SUMO5_HUMAN (1-101): 4.52e-41: 132: 88.12		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		928183 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		129548 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		1020815 NF2IP_HUMAN (10-90): 2.19e-25: 99.4: 26.83		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		129580 NF2IP_HUMAN (10-90): 2.19e-25: 99.4: 26.83		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		1024714 NF2IP_HUMAN (10-90): 2.19e-25: 99.4: 26.83		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		902558 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		1023724 NF2IP_HUMAN (10-90): 2.19e-25: 99.4: 26.83		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		902583 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		928187 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		902556 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59