Protein: HAP1
Huntingtin-associated protein 1 (HAP-1) (Neuroan 1)

Gene: HAP1
Organism: Homo sapiens
Interactions: 113
UniProt ID: P54257

Gene Ontology (top 5):
GO:0005102 - signaling receptor binding
GO:0005730 - nucleolus
GO:0005739 - mitochondrion
GO:0005764 - lysosome
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

843411

HD
Huntingtin

6

6

Small-scale

0.743

High

169486

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

6

Small-scale

0.675

High

928164

HAP1
Huntingtin-associated protein 1

3

18

Small-scale

0.660

High

928180

DCTN1
Dynactin subunit 1

2

17

Small-scale

0.642

High

860670

RS10
Small ribosomal subunit protein eS10

2

2

High-throughput

0.620

High

928166

HDAC4
Histone deacetylase 4

2

17

High-throughput

0.606

High

928168

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

1

High-throughput

0.606

High

928172

CDK18
Cyclin-dependent kinase 18

2

13

High-throughput

0.606

High

928185

PKN1
Serine/threonine-protein kinase N1

2

6

High-throughput

0.606

High

928193

PPR18
Phostensin

2

6

High-throughput

0.606

High

928200

CCD13
Coiled-coil domain-containing protein 13

2

19

High-throughput

0.606

High

928204

RHPN1
Rhophilin-1

2

3

High-throughput

0.606

High

928205

AEN
Apoptosis-enhancing nuclease

2

2

High-throughput

0.606

High

926896

ATX3
Ataxin-3

2

2

Small-scale

0.601

High

928226

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

2

0

High-throughput

0.594

High

478667

HXB5
Homeobox protein Hox-B5

2

0

High-throughput

0.580

High

65875

MSGN1
Mesogenin-1

2

2

High-throughput

0.553

High

928184

ZN124
Zinc finger protein 124

2

2

High-throughput

0.553

High

928190

ZN648
Zinc finger protein 648

2

2

High-throughput

0.553

High

928196

ZFP1
Zinc finger protein 1 homolog

2

2

High-throughput

0.553

High

928197

ZN572
Zinc finger protein 572

2

2

High-throughput

0.553

High

928199

ZN575
Zinc finger protein 575

2

1

High-throughput

0.553

High

928237

ZN490
Zinc finger protein 490

2

2

High-throughput

0.553

High

928239

ZN835
Zinc finger protein 835

2

2

High-throughput

0.553

High

928177

NDF1
Neurogenic differentiation factor 1

1

1

Small-scale

0.552

High

333314

SNAPN
SNARE-associated protein Snapin

1

3

High-throughput

0.541

High

852104

TNNT3
Troponin T, fast skeletal muscle

1

2

High-throughput

0.541

High

894460

PPOX
Protoporphyrinogen oxidase

1

1

High-throughput

0.541

High

928174

PPID
Peptidyl-prolyl cis-trans isomerase D

1

3

High-throughput

0.541

High

928175

STX5
Syntaxin-5

1

3

High-throughput

0.541

High

928183

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

2

High-throughput

0.541

High

928213

CK5P2
CDK5 regulatory subunit-associated protein 2

1

19

High-throughput

0.541

High

928244

DDX49
Probable ATP-dependent RNA helicase DDX49

1

2

High-throughput

0.541

High

660251

BDNF
Neurotrophic factor BDNF precursor form

1

0

Small-scale

0.537

High

171208

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

6

High-throughput

0.536

High

821081

TXLNA
Alpha-taxilin

1

18

High-throughput

0.536

High

928178

ASPP2
Apoptosis-stimulating of p53 protein 2

1

7

High-throughput

0.536

High

928187

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.536

High

928195

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

4

High-throughput

0.536

High

928198

HOOK3
Protein Hook homolog 3

1

19

High-throughput

0.536

High

928232

TXLNG
Gamma-taxilin

1

15

High-throughput

0.536

High

928236

MKLN1
Muskelin

1

8

High-throughput

0.536

High

928201

AHI1
Jouberin

1

6

Small-scale

0.529

High

331981

KAT7
Histone acetyltransferase KAT7

1

1

High-throughput

0.527

High

928209

KAT5
Histone acetyltransferase KAT5

1

1

High-throughput

0.527

High

928240

GIT1
ARF GTPase-activating protein GIT1

1

1

High-throughput

0.527

High

928171

ZN33B
Zinc finger protein 33B

2

1

High-throughput

0.526

High

127907

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.518

High

184148

RER1
Protein RER1

1

0

High-throughput

0.518

High

928165

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.518

High

928167

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.518

High

928169

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.518

High

928170

RT09
Small ribosomal subunit protein uS9m

1

0

High-throughput

0.518

High

928220

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

1

0

High-throughput

0.518

High

928222

KTBL1
KATNB1-like protein 1

1

0

High-throughput

0.518

High

928231

SAS10
Something about silencing protein 10

1

0

High-throughput

0.518

High

928233

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.518

High

928235

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.518

High

928243

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.518

High

928181

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.513

High

928241

NOSIP
Nitric oxide synthase-interacting protein

1

0

High-throughput

0.513

High

568546

TNNT1
Troponin T, slow skeletal muscle

1

2

High-throughput

0.508

High

928194

CDC73
Parafibromin

1

1

High-throughput

0.508

High

928217

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.504

High

761604

HSP74
Heat shock 70 kDa protein 4

1

5

Small-scale

0.501

High

261776

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.494

High

600083

ZNF20
Zinc finger protein 20

1

3

High-throughput

0.494

High

600275

ZNF24
Zinc finger protein 24

1

7

High-throughput

0.494

High

894302

CRIP1
Cysteine-rich protein 1

1

3

High-throughput

0.494

High

928173

SRSF4
Serine/arginine-rich splicing factor 4

1

1

High-throughput

0.494

High

928176

MPP3
MAGUK p55 subfamily member 3

1

3

High-throughput

0.494

High

928179

CO9A2

1

1

High-throughput

0.494

High

928191

ZN691
Zinc finger protein 691

1

1

High-throughput

0.494

High

928212

NP1L5
Nucleosome assembly protein 1-like 5

1

2

High-throughput

0.494

High

928229

CBX8
Chromobox protein homolog 8

1

1

High-throughput

0.494

High

628735

TBP
TATA-box-binding protein

1

0

High-throughput

0.486

High

928218

BARD1
BRCA1-associated RING domain protein 1

1

4

High-throughput

0.481

High

474571

VIME
Vimentin

1

12

High-throughput

0.481

High

928186

MIC60
MICOS complex subunit MIC60

1

3

High-throughput

0.481

High

928206

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

3

High-throughput

0.481

High

928224

TSYL1
Testis-specific Y-encoded-like protein 1

1

2

High-throughput

0.481

High

928228

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

1

Small-scale

0.481

High

928230

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.481

High

238808

KALRN
Kalirin

1

17

Small-scale

0.479

High

667234

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

928215

SORT
Sortilin

1

3

Small-scale

0.479

High

910824

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

928182

PCM1
Pericentriolar material 1 protein

1

0

Small-scale

0.460

High

928210

GASP2
G-protein coupled receptor-associated sorting protein 2

1

0

High-throughput

0.460

High

928214

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

928225

CENPH
Centromere protein H

1

0

High-throughput

0.458

High

907300

APLP1
Amyloid beta precursor like protein 1

1

2

High-throughput

0.439

High

249968

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.438

High

928216

TI17A
Mitochondrial import inner membrane translocase subunit Tim17-A

1

0

High-throughput

0.438

High

928192

Q6FI91
TSPYL protein

1

2

High-throughput

0.417

High

719889

HMOX2
Heme oxygenase 2

2

0

High-throughput

0.323

High

928227

CH033
UPF0488 protein C8orf33

2

0

High-throughput

0.323

High

928188

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

928203

CA216
UPF0500 protein C1orf216

2

0

High-throughput

0.316

High

928207

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.316

High

928211

ZMAT2
Zinc finger matrin-type protein 2

2

0

High-throughput

0.316

High

928221

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.316

High

928238

FA50B
Protein FAM50B

2

0

High-throughput

0.316

High

928202

PDCD7
Programmed cell death protein 7

1

0

High-throughput

0.282

High

928223

CF263
Cilia- and flagella-associated protein 263

1

0

High-throughput

0.282

High

215792

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

0

High-throughput

0.279

Low

928234

IMPCT
Protein IMPACT

1

0

High-throughput

0.279

Low

332143

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

0

High-throughput

0.275

Low

928219

CG025
UPF0415 protein C7orf25

1

0

High-throughput

0.265

Low

928189

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

928208

ING5
Inhibitor of growth protein 5

1

0

High-throughput

0.251

Low

928242

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025