HitPredict

Interactor 1: DYL1 (P63167)
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
Gene: DYNLL1

Interactor 2: DC1I2 (Q13409)
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)
Gene: DYNC1I2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	28718761, 26496610, 17353931, 33961781, 35271311, 24986880
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, electron microscopy, molecular sieving
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Dynein_IC2~Dynein_light
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0005868 - cytoplasmic dynein complex GO:0005874 - microtubule and 1 others more... GO:0030286 - dynein complex
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 89 Hs			1 638
+	Hs
		1033319 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		DC1I2_HUMAN (1-638): 3.3e-143: 432: 100.00
+	Hs
		148059 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		DC1I1_HUMAN (1-638): 2.67e-129: 396: 75.04
+	Mm
		291681 DYL1_MOUSE (1-89): 1.96e-46: 145: 100.00		DC1I1_MOUSE (1-638): 1.53e-129: 396: 76.02
+	Hs
		148093 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		DC1I1_HUMAN (1-638): 2.67e-129: 396: 75.04
+	Dm
		1096026 DYL1_DROME (1-89): 1.36e-46: 145: 94.38		DYIN_DROME (6-627): 1.06e-105: 336: 46.39
+	Ce
		219878 DYL1_CAEEL (1-89): 8.25e-46: 143: 92.14		O45087_CAEEL (7-629): 1.21e-99: 319: 34.53
+	Hs
		928412 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		DC2I1_HUMAN (32-630): 1.48e-84: 288: 15.36
+	Hs
		1261759 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		DC2I1_HUMAN (32-630): 1.48e-84: 288: 15.36
+	Hs
		928426 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		DC2I2_HUMAN (190-623): 5.08e-84: 275: 19.75
+	Hs
		1290452 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		DC2I2_HUMAN (190-623): 5.08e-84: 275: 19.75
+	Cr
		65477 A8IRP4_CHLRE (13-88): 3.51e-26: 94.7: 43.37		A8IJZ3_CHLRE (191-635): 7.41e-86: 281: 21.74
+	Hs
		792964 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		LIS1_HUMAN (472-631): 9.12e-32: 129: 16.88
+	Hs
		793023 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		LIS1_HUMAN (472-631): 9.12e-32: 129: 16.88
+	Hs
		928431 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		WDR90_HUMAN (295-601): 1.02e-15: 83.4: 15.73