HitPredict

Interactor 1: AMPH (Q7TQF7)
Amphiphysin
Gene: AMPH

Interactor 2: AP2B1 (Q9DBG3)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	31291551
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0044877 - protein-containing complex binding GO:0045807 - positive regulation of endocytosis GO:0048488 - synaptic vesicle endocytosis GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 686 Mm			1 937
+	Rn
		139975 AMPH_RAT (1-686): 1.11e-113: 359: 92.14		AP2B1_RAT (1-937): 0: 924: 99.89
+	Hs
		827733 AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		827743 AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Hs
		203219 SYNJ1_HUMAN (38-650): 2.06e-38: 155: 12.62		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		925856 EP300_HUMAN (107-613): 6.64e-31: 132: 11.92		AP2B1_HUMAN (1-937): 0: 924: 99.89
+	Hs
		203223 SYNJ1_HUMAN (38-650): 2.06e-38: 155: 12.62		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Hs
		998610 EP300_HUMAN (107-613): 6.64e-31: 132: 11.92		AP1B1_HUMAN (1-937): 0: 887: 82.72
+	Mm
		567528 AMPH_MOUSE (1-686): 7.42e-129: 398: 100.00		AP2A2_MOUSE (11-932): 0: 600: 16.29
+	Hs
		321511 AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Rn
		88753 AMPH_RAT (1-686): 1.11e-113: 359: 92.14		D3ZUY8_RAT (11-932): 0: 625: 17.04
+	Hs
		302118 AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16		AP2A2_HUMAN (11-933): 0: 604: 16.89
+	Rn
		139980 AMPH_RAT (1-686): 1.11e-113: 359: 92.14		Q66HM2_RAT (11-932): 0: 595: 16.17
+	Hs
		212606 AMPH_HUMAN (1-686): 2.96e-112: 355: 82.16		AP1G1_HUMAN (11-808): 0: 549: 17.57
+	Hs
		203194 SYNJ1_HUMAN (38-650): 2.06e-38: 155: 12.62		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Hs
		321533 EP300_HUMAN (107-613): 6.64e-31: 132: 11.92		AP2A1_HUMAN (11-932): 0: 634: 16.77
+	Rn
		1144064 SYNJ1_RAT (38-650): 1.74e-37: 152: 11.57		Q66HM2_RAT (11-932): 0: 595: 16.17
+	Hs
		302143 EP300_HUMAN (107-613): 6.64e-31: 132: 11.92		AP2A2_HUMAN (11-933): 0: 604: 16.89
+	Hs
		863212 EP300_HUMAN (107-613): 6.64e-31: 132: 11.92		COPB_HUMAN (8-927): 0: 567: 12.88
+	Hs
		212623 EP300_HUMAN (107-613): 6.64e-31: 132: 11.92		AP1G1_HUMAN (11-808): 0: 549: 17.57
+	Hs
		119953 EP300_HUMAN (107-613): 6.64e-31: 132: 11.92		AP3B1_HUMAN (8-594): 1.21e-177: 546: 28.17