HitPredict

Interactor 1: DYL1 (P63167)
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
Gene: DYNLL1

Interactor 2: DC2I1 (Q8WVS4)
Cytoplasmic dynein 2 intermediate chain 1 (Dynein 2 intermediate chain 1) (WD repeat-containing protein 60)
Gene: DYNC2I1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005868 - cytoplasmic dynein complex GO:0005929 - cilium GO:0035721 - intraciliary retrograde transport and 1 others more... GO:0097542 - ciliary tip
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 89 Hs			1 1066
+	Hs
		1261759 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		DC2I1_HUMAN (1-1066): 0: 812: 100.00
+	Hs
		148059 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		DC1I1_HUMAN (376-1056): 5.44e-177: 533: 16.90
+	Mm
		291681 DYL1_MOUSE (1-89): 1.96e-46: 145: 100.00		DC1I1_MOUSE (376-1056): 3.36e-177: 533: 17.60
+	Hs
		148093 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		DC1I1_HUMAN (376-1056): 5.44e-177: 533: 16.90
+	Hs
		928281 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		DC1I2_HUMAN (382-1056): 3.33e-166: 505: 16.71
+	Hs
		1033319 DYL2_HUMAN (1-89): 1.68e-45: 142: 93.26		DC1I2_HUMAN (382-1056): 3.33e-166: 505: 16.71
+	Dm
		1096026 DYL1_DROME (1-89): 1.36e-46: 145: 94.38		DYIN_DROME (566-1056): 3.64e-112: 364: 19.68
+	Ce
		219878 DYL1_CAEEL (1-89): 8.25e-46: 143: 92.14		O45087_CAEEL (338-1056): 3.02e-64: 231: 15.72
+	Hs
		551662 DYL1_HUMAN (1-89): 1.96e-46: 145: 100.00		DESP_HUMAN (1-554): 5.69e-14: 79.3: 12.35