HitPredict

Interactor 1: E9PTH2 (E9PTH2)
Mitogen-activated protein kinase (EC 2.7.11.24)
Gene: Mapk7

Interactor 2: HS90B (P34058)
Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84)
Gene: Hsp90ab1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23428871
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 812 Rn			1 724
+	Mm
		513710 MK07_MOUSE (1-812): 0: 659: 97.41		HS90B_MOUSE (1-724): 0: 1083: 100.00
+	Hs
		438129 MK07_HUMAN (1-812): 0: 641: 88.37		HS90B_HUMAN (1-724): 0: 1079: 99.59
+	Hs
		431807 MK07_HUMAN (1-812): 0: 641: 88.37		HS90A_HUMAN (1-724): 0: 1066: 85.66
+	Hs
		538216 MK07_HUMAN (1-812): 0: 641: 88.37		ENPL_HUMAN (3-696): 0: 912: 46.38
+	Hs
		438208 MK14_HUMAN (41-388): 7.45e-151: 447: 45.40		HS90B_HUMAN (1-724): 0: 1079: 99.59
+	Hs
		431896 MK14_HUMAN (41-388): 7.45e-151: 447: 45.40		HS90A_HUMAN (1-724): 0: 1066: 85.66
+	Hs
		437913 MK03_HUMAN (26-390): 1.87e-143: 429: 48.22		HS90B_HUMAN (1-724): 0: 1079: 99.59
+	Rn
		600340 MK03_RAT (26-390): 4.13e-142: 425: 47.95		HS90B_RAT (1-724): 0: 1083: 100.00
+	Mm
		432419 MK01_MOUSE (33-390): 1.41e-146: 436: 48.60		HS90A_MOUSE (1-724): 0: 1062: 84.72
+	Hs
		431555 MK03_HUMAN (26-390): 1.87e-143: 429: 48.22		HS90A_HUMAN (1-724): 0: 1066: 85.66
+	Rn
		600383 MK03_RAT (26-390): 4.13e-142: 425: 47.95		HS90A_RAT (1-724): 0: 1064: 84.86
+	Mm
		432433 MK03_MOUSE (26-390): 3.4e-142: 426: 47.95		HS90A_MOUSE (1-724): 0: 1062: 84.72
+	At
		850798 MPK10_ARATH (7-395): 2.48e-143: 429: 42.82		HS903_ARATH (10-724): 0: 1001: 66.71
+	Sc
		543134 FUS3_YEAST (47-385): 5.28e-151: 447: 48.29		HSC82_YEAST (13-724): 0: 919: 60.36
+	Sc
		366740 SLT2_YEAST (33-500): 1.39e-144: 436: 39.03		HSP82_YEAST (12-724): 0: 924: 61.40
+	Sc
		365984 HOG1_YEAST (33-390): 6.36e-145: 435: 44.41		HSP82_YEAST (12-724): 0: 924: 61.40
+	Sc
		543393 HOG1_YEAST (33-390): 6.36e-145: 435: 44.41		HSC82_YEAST (13-724): 0: 919: 60.36
+	Rn
		600453 MK03_RAT (26-390): 4.13e-142: 425: 47.95		ENPL_RAT (3-696): 0: 917: 45.82
+	Dm
		772971 ERKA_DROME (23-394): 2.44e-142: 426: 47.04		Q9VAY2_DROME (4-692): 0: 845: 46.29
+	Sc
		365698 KSS1_YEAST (47-361): 4.46e-104: 327: 51.69		HSP82_YEAST (12-724): 0: 924: 61.40