HitPredict

Interactor 1: TERF1 (P54274)
Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1)
Gene: TERF1

Interactor 2: POTE1 (Q9NUX5)
Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)
Gene: POT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

The method score is based on:

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781, 20811636, 12768206, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0000783 - nuclear telomere cap complex GO:0005654 - nucleoplasm GO:0007004 - telomere maintenance via telomerase GO:0016233 - telomere capping and 6 others more... GO:0032206 - positive regulation of telomere maintenance GO:0032211 - negative regulation of telomere maintenance via telomerase GO:0042162 - telomeric DNA binding GO:0061820 - telomeric D-loop disassembly GO:0070187 - shelterin complex GO:0098505 - G-rich strand telomeric DNA binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	439
Hs

1	634

Service provided by Combinatics, Japan

Last updated: 11Aug2025