Protein: POTE1
Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)

Gene: POTE1, POT1
Organism: Homo sapiens
Interactions: 231
UniProt ID: Q9NUX5

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0000783 - nuclear telomere cap complex
GO:0005654 - nucleoplasm
GO:0007004 - telomere maintenance via telomerase
GO:0010521 - telomerase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1383378

ACD
Adrenocortical dysplasia protein homolog

13

3

Small-scale

0.764

High

1150006

TERF2
Telomeric repeat-binding factor 2

8

1

Small-scale

0.755

High

928565

TERF1
Telomeric repeat-binding factor 1

7

1

Small-scale

0.745

High

1412513

TINF2
TERF1-interacting nuclear factor 2

11

0

Small-scale

0.728

High

1450174

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

6

0

Small-scale

0.706

High

1179197

CTC1
CST complex subunit CTC1

1

1

Small-scale

0.621

High

1434831

STN1
CST complex subunit STN1

1

1

Small-scale

0.621

High

1450189

COF2
Cofilin-2

3

3

High-throughput

0.597

High

1450171

POTE1
Protection of telomeres protein 1

1

0

Small-scale

0.586

High

163596

TPP1
Tripeptidyl-peptidase 1

2

1

Small-scale

0.570

High

1052109

CALD1
Caldesmon

2

1

High-throughput

0.566

High

799508

BRCA1
Breast cancer type 1 susceptibility protein

2

0

Small-scale

0.559

High

316061

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.552

High

1150895

CIP4
Cdc42-interacting protein 4

1

3

High-throughput

0.552

High

1450184

DD19B
ATP-dependent RNA helicase DDX19B

1

2

High-throughput

0.552

High

1450185

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.552

High

1450188

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.552

High

483974

HMOX1
Heme oxygenase 1

1

0

High-throughput

0.549

High

1382461

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.549

High

1411555

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.549

High

1450195

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

0

High-throughput

0.549

High

123448

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.529

High

214513

HXA3
Homeobox protein Hox-A3

1

0

High-throughput

0.529

High

226997

ENSA
Alpha-endosulfine

1

0

High-throughput

0.529

High

271298

CPNE3
Copine-3

1

0

High-throughput

0.529

High

292479

PALM
Paralemmin-1

1

0

High-throughput

0.529

High

347958

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.529

High

468844

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.529

High

476847

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.529

High

615242

IL1RA
Interleukin-1 receptor antagonist protein

1

0

High-throughput

0.529

High

714978

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.529

High

882571

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.529

High

893450

HNMT
Histamine N-methyltransferase

1

0

High-throughput

0.529

High

953136

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.529

High

1293567

F131B
Protein FAM131B

1

0

High-throughput

0.529

High

1309374

ARI3B
AT-rich interactive domain-containing protein 3B

1

0

High-throughput

0.529

High

1450172

ANM7
Protein arginine N-methyltransferase 7

1

0

High-throughput

0.529

High

1450175

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

1

0

High-throughput

0.529

High

1450192

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.529

High

224549

ST1B1
Sulfotransferase 1B1

1

2

High-throughput

0.523

High

456867

ANXA2
Annexin A2

1

1

High-throughput

0.523

High

722815

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

1

High-throughput

0.523

High

1392391

PAGE5
P antigen family member 5

1

2

High-throughput

0.523

High

1411008

ST4A1
Sulfotransferase 4A1

1

2

High-throughput

0.523

High

1417656

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

2

High-throughput

0.523

High

1028412

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.518

High

1059980

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.518

High

166199

AIM2
Interferon-inducible protein AIM2

1

0

High-throughput

0.513

High

558439

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.513

High

832335

ID1
DNA-binding protein inhibitor ID-1

1

0

High-throughput

0.513

High

1008379

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.513

High

1436045

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.513

High

132946

ST1C2
Sulfotransferase 1C2

1

2

High-throughput

0.504

High

358811

LDHA
L-lactate dehydrogenase A chain

1

1

High-throughput

0.504

High

451080

LDHB
L-lactate dehydrogenase B chain

1

1

High-throughput

0.504

High

457925

INVO
Involucrin

1

1

High-throughput

0.504

High

483462

ANXA4
Annexin A4

1

1

High-throughput

0.504

High

660177

COF1
Cofilin-1

1

3

High-throughput

0.504

High

698378

MAP4
Microtubule-associated protein 4

1

1

High-throughput

0.504

High

731641

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.504

High

786355

PGM1
Phosphoglucomutase-1

1

1

High-throughput

0.504

High

966930

1433G
14-3-3 protein gamma

1

1

High-throughput

0.504

High

997532

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.504

High

1118613

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.504

High

1124554

MAP7
Ensconsin

1

1

High-throughput

0.504

High

1133179

LASP1
LIM and SH3 domain protein 1

1

2

High-throughput

0.504

High

1153744

TOM34
Mitochondrial import receptor subunit TOM34

1

1

High-throughput

0.504

High

1160774

DREB
Drebrin

1

1

High-throughput

0.504

High

1233720

TWF2
Twinfilin-2

1

3

High-throughput

0.504

High

1275891

PAGE2
P antigen family member 2

1

2

High-throughput

0.504

High

1358116

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.504

High

1391234

PGM2
Phosphopentomutase

1

1

High-throughput

0.504

High

1392387

XAGE2
X antigen family member 2

1

2

High-throughput

0.504

High

1450183

DBNL
Drebrin-like protein

1

4

High-throughput

0.504

High

1450186

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

2

High-throughput

0.504

High

516176

HS71A
Heat shock 70 kDa protein 1A

1

0

High-throughput

0.493

High

1051970

KPCD
Protein kinase C delta type

1

0

High-throughput

0.493

High

1295725

HORN
Hornerin

1

1

High-throughput

0.489

High

1217210

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.481

High

679268

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.479

High

1089032

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1129760

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1450191

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.479

High

1200670

Q549N0
Cofilin 2

1

3

High-throughput

0.470

High

298097

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.460

High

995300

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.460

High

1254106

ZBT49
Zinc finger and BTB domain-containing protein 49

1

0

High-throughput

0.460

High

162973

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.458

High

332453

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

0

Small-scale

0.458

High

404469

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

586916

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

655353

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

High-throughput

0.458

High

809874

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

967580

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

969476

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

979288

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

980413

H4
Histone H4

1

0

High-throughput

0.458

High

1146844

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1368498

CBP
CREB-binding protein

1

0

High-throughput

0.458

High

1399765

RBM14
RNA-binding protein 14

1

0

High-throughput

0.458

High

1417821

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

1429802

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.458

High

141676

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.437

High

193151

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

1

High-throughput

0.437

High

366555

TPA
Tissue-type plasminogen activator

1

1

High-throughput

0.437

High

424276

S10A8
Protein S100-A8

1

1

High-throughput

0.437

High

552483

FA5
Coagulation factor V

1

1

High-throughput

0.437

High

724642

S10A7
Protein S100-A7

1

2

High-throughput

0.437

High

1117509

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

High-throughput

0.437

High

1151669

TRIP6
Thyroid receptor-interacting protein 6

1

1

Small-scale

0.437

High

1280755

YTHD3
YTH domain-containing family protein 3

1

2

High-throughput

0.437

High

1359608

ATX2L
Ataxin-2-like protein

1

1

High-throughput

0.437

High

1372014

LPP
Lipoma-preferred partner

1

1

Small-scale

0.437

High

1418352

TMPSD
Transmembrane protease serine 13

1

1

High-throughput

0.437

High

1418739

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.437

High

1450178

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.437

High

1450196

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.437

High

249787

DOK2
Docking protein 2

1

0

High-throughput

0.299

High

317480

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

0

High-throughput

0.299

High

348892

CLIC3
Chloride intracellular channel protein 3

1

0

High-throughput

0.299

High

848356

MAGA4
Melanoma-associated antigen 4

1

0

High-throughput

0.299

High

863198

3HAO
3-hydroxyanthranilate 3,4-dioxygenase

1

0

High-throughput

0.299

High

897556

BPL1
Biotin--protein ligase

1

0

High-throughput

0.299

High

993910

TYB10
Thymosin beta-10

1

0

High-throughput

0.299

High

1028535

PDE1B
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

1

0

High-throughput

0.299

High

1042715

KIME
Mevalonate kinase

1

0

High-throughput

0.299

High

1087694

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

0

High-throughput

0.299

High

1210390

PHYD1
Phytanoyl-CoA dioxygenase domain-containing protein 1

1

0

High-throughput

0.299

High

1245449

CNST
Consortin

1

0

High-throughput

0.299

High

1292675

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.299

High

1308119

AT2L2
5-phosphohydroxy-L-lysine phospho-lyase

1

0

High-throughput

0.299

High

1360625

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.299

High

1382673

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.299

High

1407323

GPA33
Cell surface A33 antigen

1

0

High-throughput

0.299

High

1414845

CCD32
Coiled-coil domain-containing protein 32

1

0

High-throughput

0.299

High

1416238

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.299

High

1446374

INO1
Inositol-3-phosphate synthase 1

1

0

High-throughput

0.299

High

1450176

SOX
Peroxisomal sarcosine oxidase

1

0

High-throughput

0.299

High

1162906

H2A2C
Histone H2A type 2-C

1

0

Small-scale

0.292

High

158671

TYB4Y
Thymosin beta-4, Y-chromosomal

1

0

High-throughput

0.288

High

220451

RGS14
Regulator of G-protein signaling 14

1

0

High-throughput

0.288

High

221217

DNPH1
5-hydroxymethyl-dUMP N-hydrolase

1

0

High-throughput

0.288

High

221294

DCX
Neuronal migration protein doublecortin

1

0

High-throughput

0.288

High

262163

NOL3
Nucleolar protein 3

1

0

High-throughput

0.288

High

295245

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.288

High

302712

SYUG
Gamma-synuclein

1

0

High-throughput

0.288

High

333838

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.288

High

334361

TRI16
Tripartite motif-containing protein 16

1

0

High-throughput

0.288

High

354788

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.288

High

409098

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.288

High

456118

FES
Tyrosine-protein kinase Fes/Fps

1

0

High-throughput

0.288

High

479172

ENOG
Gamma-enolase

1

0

High-throughput

0.288

High

482546

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.288

High

553288

KCRB
Creatine kinase B-type

1

0

High-throughput

0.288

High

653777

CRYGS
Gamma-crystallin S

1

0

High-throughput

0.288

High

659845

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.288

High

660740

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.288

High

855777

CRK
Adapter molecule crk

1

0

High-throughput

0.288

High

873869

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.288

High

884796

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.288

High

896315

PEX5
Peroxisomal targeting signal 1 receptor

1

0

High-throughput

0.288

High

912612

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.288

High

949212

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.288

High

972052

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.288

High

1009821

MT1X
Metallothionein-1X

1

0

High-throughput

0.288

High

1030336

AMPD2
AMP deaminase 2

1

0

High-throughput

0.288

High

1032556

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.288

High

1034532

TAGL
Transgelin

1

0

High-throughput

0.288

High

1041466

ACY1
Aminoacylase-1

1

0

High-throughput

0.288

High

1059239

TISB
mRNA decay activator protein ZFP36L1

1

0

High-throughput

0.288

High

1068320

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.288

High

1089184

IFRD2
Interferon-related developmental regulator 2

1

0

High-throughput

0.288

High

1123279

DPYL3
Dihydropyrimidinase-related protein 3

1

0

High-throughput

0.288

High

1125966

GAMT
Guanidinoacetate N-methyltransferase

1

0

High-throughput

0.288

High

1131935

GNMT
Glycine N-methyltransferase

1

0

High-throughput

0.288

High

1177249

MICA
MHC class I polypeptide-related sequence A

1

0

High-throughput

0.288

High

1244285

ZN790
Zinc finger protein 790

1

0

High-throughput

0.288

High

1306972

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

0

High-throughput

0.288

High

1308407

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

0

High-throughput

0.288

High

1327007

AF1L2
Actin filament-associated protein 1-like 2

1

0

High-throughput

0.288

High

1337803

DP13B
DCC-interacting protein 13-beta

1

0

High-throughput

0.288

High

1386070

NXNL1
Nucleoredoxin-like protein 1

1

0

High-throughput

0.288

High

1395583

PDLI2
PDZ and LIM domain protein 2

1

0

High-throughput

0.288

High

1404988

GA2L1
GAS2-like protein 1

1

0

High-throughput

0.288

High

1411112

CPPED
Serine/threonine-protein phosphatase CPPED1

1

0

High-throughput

0.288

High

1412850

CCM2
Cerebral cavernous malformations 2 protein

1

0

High-throughput

0.288

High

1413744

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.288

High

1433171

RBSK
Ribokinase

1

0

High-throughput

0.288

High

1433639

E41L1
Band 4.1-like protein 1

1

0

High-throughput

0.288

High

1446924

RTN4
Reticulon-4

1

0

High-throughput

0.288

High

1450173

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.288

High

1450177

NCDN
Neurochondrin

1

0

High-throughput

0.288

High

1450179

BIN2
Bridging integrator 2

1

0

High-throughput

0.288

High

1450181

EVL
Ena/VASP-like protein

1

0

High-throughput

0.288

High

1450190

GPR52
G-protein coupled receptor 52

1

0

High-throughput

0.288

High

1450193

3BP1
SH3 domain-binding protein 1

1

0

High-throughput

0.288

High

1450194

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.288

High

224811

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.282

High

358905

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.282

High

437019

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.282

High

600592

ZNF32
Zinc finger protein 32

1

0

High-throughput

0.282

High

705575

GRN
Progranulin

1

0

High-throughput

0.282

High

837370

ECI1
Enoyl-CoA delta isomerase 1, mitochondrial

1

0

High-throughput

0.282

High

936874

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.282

High

1035484

CX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial

1

0

High-throughput

0.282

High

1413598

ZBED2
Zinc finger BED domain-containing protein 2

1

0

High-throughput

0.282

High

1438315

CP4FB
Cytochrome P450 4F11

1

0

High-throughput

0.282

High

347364

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

933359

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.279

Low

1213848

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.279

Low

1256997

FBX50
F-box only protein 50

1

0

High-throughput

0.279

Low

1272124

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

1333397

AVL9
Late secretory pathway protein AVL9 homolog

1

0

High-throughput

0.279

Low

1271016

RHOU
Rho-related GTP-binding protein RhoU

1

0

High-throughput

0.261

Low

71873

CB074
Uncharacterized protein C2orf74

1

0

High-throughput

0.251

Low

724428

COR1A
Coronin-1A

1

0

High-throughput

0.251

Low

1132006

MVP
Major vault protein

1

0

High-throughput

0.251

Low

1447553

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.251

Low

1450180

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.251

Low

1450197

LAMC3
Laminin subunit gamma-3

1

0

High-throughput

0.251

Low

643569

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.249

Low

755379

ABCD1
ATP-binding cassette sub-family D member 1

1

0

High-throughput

0.249

Low

1120136

CYLC2
Cylicin-2

1

0

High-throughput

0.249

Low

1213392

CFA58
Cilia- and flagella-associated protein 58

1

0

High-throughput

0.249

Low

1219476

SLX4I
Protein SLX4IP

1

0

Small-scale

0.249

Low

1325638

RGF1C
Ras-GEF domain-containing family member 1C

1

0

High-throughput

0.249

Low

1396909

SNX22
Sorting nexin-22

1

0

High-throughput

0.249

Low

1450182

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1450187

CP131
Centrosomal protein of 131 kDa

1

0

High-throughput

0.249

Low

1227551

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025