HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.980

The method score is based on:

Property Details
Experiments 27705803, 33961781, 21946088, 26087183, 18498745, 31343991, 12481031, 34478796, 17205132, 21572988, 22388891, 15070733, 20596027
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0031467 - Cul7-RING ubiquitin ligase complex
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 163
Hs

1 598
+ Mm
+ Mm
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+ Mm
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+ Sp
+ Mm
+ Hs
+ Xl
+ Hs
+ Sp
+ Hs
+ Hs
+ Dm
+ Ce
+ Sp
+ Dm
+ Dm
+ Dm
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024