Protein: ESS1
Peptidyl-prolyl cis-trans isomerase ESS1 (PPIase ESS1) (EC 5.2.1.8) (Parvulin ESS1) (Processing/termination factor 1)

Gene: ESS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 133
UniProt ID: P22696

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000993 - RNA polymerase II complex binding
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005634 - nucleus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

401891

RPB1
DNA-directed RNA polymerase II subunit RPB1

13

2

Small-scale

0.760

High

594195

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

0

Small-scale

0.657

High

651983

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.656

High

454704

KAPR
cAMP-dependent protein kinase regulatory subunit

2

1

High-throughput

0.619

High

525952

HSP72
Heat shock protein SSA2

3

0

High-throughput

0.613

High

470465

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

651900

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.575

High

651906

TF2B
Transcription initiation factor IIB

2

0

High-throughput

0.551

High

651920

SPT23
Protein SPT23

1

0

Small-scale

0.549

High

651905

SPT5
Transcription elongation factor SPT5

1

2

High-throughput

0.536

High

651909

PSA5
Proteasome subunit alpha type-5

1

1

High-throughput

0.536

High

651932

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.536

High

651970

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.536

High

651996

MDN1
Midasin

1

1

High-throughput

0.536

High

651912

RPD3
Histone deacetylase RPD3

1

1

Small-scale

0.515

High

464312

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

651908

HS104
Heat shock protein 104

1

0

High-throughput

0.513

High

651929

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.513

High

651950

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.513

High

651968

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.513

High

488918

SWI6
Regulatory protein SWI6

1

0

Small-scale

0.505

High

652000

WHI5
G1-specific transcriptional repressor WHI5

1

0

Small-scale

0.505

High

366772

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.501

High

367897

ENO2
Enolase 2

1

1

High-throughput

0.501

High

538322

PYC1
Pyruvate carboxylase 1

1

1

High-throughput

0.501

High

574554

YAK1
Dual specificity protein kinase YAK1

1

2

High-throughput

0.501

High

636536

PSA7
Probable proteasome subunit alpha type-7

1

3

High-throughput

0.501

High

651901

TKT1
Transketolase 1

1

1

High-throughput

0.501

High

651902

AATC
Aspartate aminotransferase, cytoplasmic

1

1

High-throughput

0.501

High

651917

LHP1
La protein homolog

1

1

High-throughput

0.501

High

651919

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.501

High

651948

MVP1
Sorting nexin MVP1

1

1

High-throughput

0.501

High

651956

YJ66
Uncharacterized oxidoreductase YJR096W

1

5

High-throughput

0.501

High

651961

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

1

High-throughput

0.501

High

651973

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.501

High

651997

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.501

High

651999

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.501

High

651904

CDC48
Cell division control protein 48

1

2

High-throughput

0.500

High

651913

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.500

High

651928

SAP30
Transcriptional regulatory protein SAP30

1

0

Small-scale

0.493

High

370437

IPA3
Protease A inhibitor 3

1

0

High-throughput

0.480

High

441715

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.480

High

446207

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.480

High

541270

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.480

High

578212

TAL1
Transaldolase

1

0

High-throughput

0.480

High

582224

AMPD
AMP deaminase

1

0

High-throughput

0.480

High

584432

IDI1
Isopentenyl-diphosphate delta-isomerase

1

0

High-throughput

0.480

High

651907

MLS1
Malate synthase 1

1

0

High-throughput

0.480

High

651915

FRDS
Fumarate reductase 1

1

0

High-throughput

0.480

High

651922

YPT53
GTP-binding protein YPT53

1

0

High-throughput

0.480

High

651925

YBQ6
Uncharacterized glycosyl hydrolase YBR056W

1

0

High-throughput

0.480

High

651931

TDA3
Putative oxidoreductase TDA3

1

0

High-throughput

0.480

High

651933

DOG2
2-deoxyglucose-6-phosphate phosphatase 2

1

0

High-throughput

0.480

High

651938

STM1
Suppressor protein STM1

1

0

High-throughput

0.480

High

651940

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.480

High

651953

YAR1
Ankyrin repeat-containing protein YAR1

1

0

High-throughput

0.480

High

651954

GON7
EKC/KEOPS complex subunit GON7

1

0

High-throughput

0.480

High

651957

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.480

High

651965

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.480

High

651969

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.480

High

651971

GOR1
Glyoxylate reductase 1

1

0

High-throughput

0.480

High

651975

PROA
Gamma-glutamyl phosphate reductase

1

0

High-throughput

0.480

High

651985

RUB1
NEDD8-like protein RUB1

1

0

High-throughput

0.480

High

651990

KYNU
Kynureninase

1

0

High-throughput

0.480

High

651992

ARR2
Arsenical-resistance protein 2

1

0

High-throughput

0.480

High

621338

METK2
S-adenosylmethionine synthase 2

1

0

High-throughput

0.479

High

626592

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

651942

IMB4
Importin subunit beta-4

1

0

High-throughput

0.479

High

651977

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.479

High

578871

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

651981

ULP1
Ubiquitin-like-specific protease 1

1

0

High-throughput

0.460

High

651939

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

651951

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

651984

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

628189

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

1

High-throughput

0.457

High

651903

YCC1
Putative uncharacterized protein YCL021W

1

1

High-throughput

0.457

High

651910

ARP2
Actin-related protein 2

1

2

High-throughput

0.457

High

651911

MDHP
Malate dehydrogenase, peroxisomal

1

1

High-throughput

0.457

High

651926

MAL32
Alpha-glucosidase MAL32

1

1

High-throughput

0.457

High

651944

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

3

High-throughput

0.457

High

651964

MALX3
Oligo-1,6-glucosidase IMA1

1

1

High-throughput

0.457

High

651976

PURA
Adenylosuccinate synthetase

1

1

High-throughput

0.457

High

381883

H4
Histone H4

1

1

High-throughput

0.445

High

543853

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

651914

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

651935

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

4

High-throughput

0.445

High

651943

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

651946

NU159
Nucleoporin NUP159

1

4

High-throughput

0.445

High

651967

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.438

High

590535

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

651921

NU120
Nucleoporin NUP120

1

0

High-throughput

0.426

High

651923

NU133
Nucleoporin NUP133

1

0

High-throughput

0.426

High

651934

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

651945

NUP82
Nucleoporin NUP82

1

0

High-throughput

0.426

High

651955

NU192
Nucleoporin NUP192

1

0

High-throughput

0.426

High

651963

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.426

High

651986

SXM1
Importin beta SMX1

1

0

High-throughput

0.426

High

651993

ASR1
Alcohol-sensitive RING finger protein 1

1

0

High-throughput

0.426

High

652001

MEX67
mRNA export factor MEX67

1

0

High-throughput

0.426

High

651978

UBC7
Ubiquitin-conjugating enzyme E2 7

1

2

High-throughput

0.417

High

577265

NSP1
Nucleoporin NSP1

1

5

High-throughput

0.407

High

651941

GLE2
mRNA export factor GLE2

1

2

High-throughput

0.407

High

651959

NUP57
Nucleoporin NUP57

1

5

High-throughput

0.407

High

651960

NU145
Nucleoporin NUP145

1

6

High-throughput

0.407

High

651979

NUP49
Nucleoporin NUP49/NSP49

1

5

High-throughput

0.407

High

651980

NU100
Nucleoporin NUP100/NSP100

1

6

High-throughput

0.407

High

651937

HXT6
High-affinity hexose transporter HXT6

1

0

High-throughput

0.279

Low

651974

EF3B
Elongation factor 3B

1

0

High-throughput

0.279

Low

150214

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.261

Low

449069

CALM
Calmodulin

1

0

High-throughput

0.261

Low

553945

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.261

Low

651916

EMP24
Endosomal protein P24B

1

0

High-throughput

0.261

Low

651924

ADCS
Aminodeoxychorismate synthase

1

0

High-throughput

0.261

Low

651930

YHE2
Putative uncharacterized protein YHL042W

1

0

High-throughput

0.261

Low

651936

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.261

Low

651949

OYE3
NADPH dehydrogenase 3

1

0

High-throughput

0.261

Low

651958

YPT11
GTP-binding protein YPT11

1

0

High-throughput

0.261

Low

651966

YGV4
Uncharacterized protein YGL204C

1

0

High-throughput

0.261

Low

651972

YNW6
Putative uncharacterized protein YNL226W

1

0

High-throughput

0.261

Low

651982

YP108
Uncharacterized protein YPL108W

1

0

High-throughput

0.261

Low

651989

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.261

Low

651991

OPT2
Oligopeptide transporter 2

1

0

High-throughput

0.261

Low

651994

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.261

Low

651995

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.261

Low

651998

YD061
Uncharacterized ABC transporter ATP-binding protein YDR061W

1

0

High-throughput

0.261

Low

651987

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low

651918

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.232

Low

651927

NU170
Nucleoporin NUP170

1

0

High-throughput

0.232

Low

651952

NUP85
Nucleoporin NUP85

1

0

High-throughput

0.232

Low

651962

NU188
Nucleoporin NUP188

1

0

High-throughput

0.232

Low

651988

NUP59
Nucleoporin ASM4

1

0

High-throughput

0.232

Low

651947

YIG0
Uncharacterized protein YIL060W

1

0

High-throughput

0.213

Low


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Last updated: 11Aug2025