HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBXL4 (Q9UKA2)
F-box/LRR-repeat protein 4 (F-box and leucine-rich repeat protein 4) (F-box protein FBL4/FBL5)
Gene: FBXL4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	27705803, 10531037, 33961781, 32877691, 36896912
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	F-box-like~Skp1
Common GO terms	GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 621
+	Mm
		1321913 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL20_MOUSE (282-619): 5.87e-59: 205: 23.49
+	Hs
		929033 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL20_HUMAN (282-619): 3.92e-59: 206: 23.74
+	Dm
		285014 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VF10_DROME (279-616): 7.54e-59: 212: 19.63
+	Ce
		105464 SKR1_CAEEL (4-162): 2.25e-78: 232: 70.81		FBXL_CAEEL (283-611): 1.37e-58: 205: 22.89
+	Hs
		929099 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL7_HUMAN (245-586): 1.31e-36: 145: 21.55
+	Hs
		928983 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL14_HUMAN (220-541): 9.42e-32: 129: 19.89
+	Hs
		928997 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		KDM2B_HUMAN (404-621): 1.48e-26: 117: 19.49
+	Hs
		929057 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL15_HUMAN (273-522): 6.94e-28: 115: 23.05
+	Dm
		284987 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q7YZ95_DROME (277-587): 2.02e-28: 121: 20.77
+	Mm
		58200 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FXL16_MOUSE (311-471): 2.01e-18: 90.6: 17.90
+	Dm
		285016 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VFN3_DROME (237-617): 1.65e-24: 110: 14.87
+	Hs
		929092 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL17_HUMAN (181-508): 2.12e-17: 88.2: 17.20
+	Hs
		929111 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL2_HUMAN (121-437): 7.52e-15: 78.9: 13.78
+	Hs
		928985 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FXL16_HUMAN (311-471): 9.28e-14: 75.9: 17.28
+	Mm
		1158242 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		KDM2B_MOUSE (214-423): 8.76e-12: 70.5: 15.00
+	Hs
		928895 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		SKP2_HUMAN (482-613): 1.36e-11: 69: 15.67
+	Mm
		1376704 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		SKP2_MOUSE (433-612): 2.23e-10: 65.1: 19.40
+	Hs
		928987 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBXL6_HUMAN (500-615): 9.42e-09: 60.1: 19.83
+	Dm
		284984 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q7K0V7_DROME (280-603): 1.16e-12: 72.8: 16.10
+	Dm
		285046 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9W214_DROME (200-433): 5.06e-11: 67.4: 15.89