HitPredict

Interactor 1: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 393
+	Hs
		734909 RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		625337 RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		734902 WDR5_HUMAN (3-219): 3.42e-62: 202: 26.70		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		854722 RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00		MP2K6_HUMAN (62-380): 7.07e-67: 216: 37.99
+	Hs
		805384 RACK1_HUMAN (1-317): 2.18e-109: 322: 100.00		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Dm
		186204 GBLP_DROME (93-316): 4.19e-49: 167: 22.88		AKT1_DROME (45-389): 1.44e-121: 366: 19.49
+	At
		1106243 GPLPC_ARATH (100-317): 1.01e-49: 169: 23.81		MPK3_ARATH (73-389): 3.24e-123: 362: 19.08
+	At
		1106623 GPLPC_ARATH (100-317): 1.01e-49: 169: 23.81		MPK6_ARATH (12-389): 7.92e-123: 362: 17.01
+	At
		1106202 GPLPB_ARATH (100-317): 1.72e-49: 168: 24.35		MPK3_ARATH (73-389): 3.24e-123: 362: 19.08
+	At
		1106574 GPLPB_ARATH (100-317): 1.72e-49: 168: 24.35		MPK6_ARATH (12-389): 7.92e-123: 362: 17.01
+	At
		189012 GBLPA_ARATH (100-317): 3.63e-49: 168: 26.41		MPK3_ARATH (73-389): 3.24e-123: 362: 19.08
+	At
		189013 GBLPA_ARATH (100-317): 3.63e-49: 168: 26.41		MPK6_ARATH (12-389): 7.92e-123: 362: 17.01
+	Hs
		625202 LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Ce
		110184 GBLP_CAEEL (50-316): 3e-58: 191: 25.61		GCK1_CAEEL (68-369): 8.97e-105: 324: 31.58
+	At
		1105322 PRL1_ARATH (3-219): 1.27e-36: 138: 19.47		KIN10_ARATH (67-393): 5.73e-124: 369: 19.34
+	At
		955193 PRL1_ARATH (3-219): 1.27e-36: 138: 19.47		KIN11_ARATH (67-393): 5.27e-122: 364: 20.54
+	Hs
		414806 LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43		CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45
+	Hs
		625543 FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		415016 FBXW7_HUMAN (3-128): 4.32e-21: 95.4: 24.63		CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45
+	At
		189107 GBLPA_ARATH (100-317): 3.63e-49: 168: 26.41		M2K9_ARATH (67-362): 7.72e-55: 184: 36.39