HitPredict

Interactor 1: KCNJ2 (P63252)
Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)
Gene: KCNJ2

Interactor 2: KCNJ2 (P63252)
Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)
Gene: KCNJ2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.843

The method score is based on:

Property Details
Experiments 29549164, 32296183, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, two hybrid prey pooling approach, validated two hybrid, two hybrid array
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains IRK~IRK, IRK~IRK_C, IRK_C~IRK_C
Common GO terms GO:0005242 - inward rectifier potassium channel activity
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005886 - plasma membrane
GO:0006813 - potassium ion transport
GO:0008076 - voltage-gated potassium channel complex
and 27 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 427
Hs

1 427
+ Mm
+ Hs
+ Gg
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Bt
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024