Protein: RNZ2
Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2)

Gene: RNZ2, ELAC2
Organism: Homo sapiens
Interactions: 151
UniProt ID: Q9BQ52

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004521 - RNA endonuclease activity
GO:0004549 - tRNA-specific ribonuclease activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1220757

RN123
E3 ubiquitin-protein ligase RNF123

3

0

High-throughput

0.634

High

1271121

TM10C
tRNA methyltransferase 10 homolog C

3

0

High-throughput

0.634

High

1410026

UBAC1
Ubiquitin-associated domain-containing protein 1

3

0

High-throughput

0.634

High

1405835

DNJC7
DnaJ homolog subfamily C member 7

3

0

High-throughput

0.622

High

1410024

RNZ2
Zinc phosphodiesterase ELAC protein 2

1

3

High-throughput

0.618

High

372980

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.613

High

946522

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

1275821

RM21
Large ribosomal subunit protein bL21m

2

0

High-throughput

0.602

High

1310346

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.585

High

1090513

TRAP1
Heat shock protein 75 kDa, mitochondrial

2

2

High-throughput

0.584

High

1153891

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.578

High

242726

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

279882

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1087515

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

1328474

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

1

High-throughput

0.536

High

814849

CUX1
Homeobox protein cut-like 1

1

0

High-throughput

0.518

High

1410036

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.518

High

1014599

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.515

High

275358

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

347283

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

457907

INVO
Involucrin

1

0

High-throughput

0.513

High

868764

LEG7
Galectin-7

1

0

High-throughput

0.513

High

869217

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

874853

SPB4
Serpin B4

1

0

High-throughput

0.513

High

1273904

BHA15
Class A basic helix-loop-helix protein 15

1

0

High-throughput

0.513

High

1370330

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1380340

GLYL1
Glycine N-acyltransferase-like protein 1

1

0

High-throughput

0.513

High

1388989

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1389180

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

1404650

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1410028

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

1410057

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1410059

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

1410061

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

288134

FOXH1
Forkhead box protein H1

1

0

Small-scale

0.493

High

1410058

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.493

High

964438

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

282056

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287359

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

801496

HSPA9
Stress-70 protein, mitochondrial

1

1

High-throughput

0.479

High

856356

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

1083719

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1135923

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

1138559

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1240323

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

1272969

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

1381109

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

1381687

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

1383548

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1386002

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1401590

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

1410025

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1410034

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1410038

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

1410051

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

1410054

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

61602

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66273

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

178044

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

0

High-throughput

0.458

High

183717

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

218688

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

260371

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

348688

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

350968

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

361656

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

412515

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

471208

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

473018

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

519209

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

532902

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

537797

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

560069

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

589529

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696337

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

766796

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

769011

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

774580

BASI
Basigin

1

0

High-throughput

0.458

High

828916

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841897

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852005

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882843

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

883320

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

970979

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

981050

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

986671

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1024156

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1048661

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058238

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1062841

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

1106297

ROCK1
Rho-associated protein kinase 1

1

0

High-throughput

0.458

High

1114130

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1117818

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1123396

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1125625

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1140757

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1142640

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1149614

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1162514

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1207119

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1234500

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1241333

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

1270617

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1290951

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

1368089

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1380639

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1384853

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1386551

OPTN
Optineurin

1

0

High-throughput

0.458

High

1387752

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1388250

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1388379

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1397097

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1397153

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

0

High-throughput

0.458

High

1397363

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1400803

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

1410027

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

1410029

TR61B
tRNA

1

0

High-throughput

0.458

High

1410030

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1410031

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1410032

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1410033

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1410035

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1410037

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1410039

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1410040

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

1410042

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1410043

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1410045

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.458

High

1410046

NGRN
Neugrin

1

0

High-throughput

0.458

High

1410047

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1410048

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

1410049

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1410050

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1410052

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1410055

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1410056

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

1410062

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1410063

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

328573

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.438

High

354386

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.426

High

653530

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

844860

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

1199672

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1406609

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.426

High

1410044

WDR6
tRNA

1

0

High-throughput

0.426

High

1410053

TRM7
tRNA

1

0

High-throughput

0.426

High

1410060

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

1255259

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1410041

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1333486

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.238

Low

1352101

S26A7
Anion exchange transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025